INT148426

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Context Info
Confidence 0.68
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 1.72
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Snap25) plasma membrane (Snap25) cytoplasm (Snap25)
Anatomy Link Frequency
retina 1
cerebral cortex 1
Brain 1
vesicle 1
cortex 1
Snap25 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 50 100.00 Very High Very High Very High
Thalamus 1 99.24 Very High Very High Very High
cerebral cortex 1 98.90 Very High Very High Very High
Sciatic nerve 16 97.88 Very High Very High Very High
Glutamate 88 97.36 Very High Very High Very High
anesthesia 12 97.06 Very High Very High Very High
Hippocampus 7 93.60 High High
isoflurane 4 92.12 High High
gABA 10 91.84 High High
agonist 14 90.80 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 50 100.00 Very High Very High Very High
Body Weight 2 89.20 High High
Poisoning 3 88.64 High High
Stress 111 88.60 High High
Depression 8 77.16 Quite High
Pain 1 76.20 Quite High
Wrinkles 1 75.12 Quite High
Injury 30 66.80 Quite High
Apoptosis 5 57.76 Quite High
Nervous System Injury 28 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Injections of BoNT/A into the optic tectum led to the appearance of BoNT/A-truncated SNAP-25 in synaptic terminals within the retina.
Gene_expression (appearance) of SNAP-25 in retina
1) Confidence 0.68 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18385327 Disease Relevance 0.15 Pain Relevance 0.16
We found that this general anesthesia causes permanent neuronal deletion in the most vulnerable brain regions-the cerebral cortex and the thalamus-while transiently modulating protein levels of synaptophysin, synaptobrevin, amphiphysin, SNAP-25, and CaM kinase II.
Gene_expression (levels) of SNAP-25 in cerebral cortex associated with anesthesia, thalamus and cerebral cortex
2) Confidence 0.59 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 18077565 Disease Relevance 0.15 Pain Relevance 0.53
Of the genes listed in Table 4, seven were found in both studies (Peripheral Benzodiazepine receptor, 5HT3, Gadd45, CLP36, Lysozyme, SNAP25 and VGF).
Gene_expression (found) of SNAP25
3) Confidence 0.53 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC139981 Disease Relevance 0.17 Pain Relevance 0.21
The pattern of expression of four genes within the DRG (Lysozyme, PACAP, MET-1 and SNAP25) were further quantified across a time course of 1, 3, 7 and 14 days post axotomy by triplicate northern slot blot (Figure 5).
Gene_expression (expression) of SNAP25 associated with dorsal root ganglion
4) Confidence 0.48 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC139981 Disease Relevance 0.38 Pain Relevance 0.17
Therefore, SNAP-25 cleavage in the visual cortex would persist for at least 1 week following BoNT/E injection.
Gene_expression (cleavage) of SNAP-25 in cortex
5) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2614467 Disease Relevance 0.09 Pain Relevance 0
Botulinum neurotoxin type E (BoNT/E) specifically cleaves synaptosomal-associated protein-25 kDa (SNAP-25) and blocks transmitter release [12], [13].
Gene_expression (cleaves) of SNAP-25
6) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2614467 Disease Relevance 0.08 Pain Relevance 0.13
Botulinum neurotoxin type E (BoNT/E) specifically cleaves synaptosomal-associated protein-25 kDa (SNAP-25) and blocks transmitter release [12], [13].
Gene_expression (cleaves) of synaptosomal-associated protein-25 kDa
7) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2614467 Disease Relevance 0.08 Pain Relevance 0.13
First, we measured the general expression of the SNAREs (synaptobrevin, syntaxin-1 and SNAP-25, the three proteins forming the core exocytotic SNARE complex) as well as their levels in synaptosomes; no changes were found in all rat groups (not shown).
Gene_expression (expression) of SNAP-25
8) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.62 Pain Relevance 0.32
g of protein) were incubated with syntaxin1/SNAP-25 (2 ?
Gene_expression (/) of SNAP-25
9) Confidence 0.19 Published 2009 Journal Neuron Section Body Doc Link PMC2697323 Disease Relevance 0 Pain Relevance 0
Brain syntaxin and SNAP-25 were purified as described (Hu et al., 2002).
Gene_expression (syntaxin) of SNAP-25 in Brain
10) Confidence 0.19 Published 2009 Journal Neuron Section Body Doc Link PMC2697323 Disease Relevance 0 Pain Relevance 0
30 interacting proteins identified, one protein ECM29 was restricted to cytosolic proteasomes, and five proteins (TAX1BP1, SNAP-25, drebrin, GRASP-1, 14-3-3?)
Gene_expression (proteins) of SNAP-25
11) Confidence 0.15 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2901091 Disease Relevance 0 Pain Relevance 0
The interaction between synaptic proteasomes and SNAP-25, a key synaptic vesicle protein (DeBello et al., 1995; Montecucco et al., 2005), may provide a mechanism for the proteolytic control of vesicle dynamics.
Gene_expression (proteasomes) of SNAP-25 in vesicle
12) Confidence 0.15 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2901091 Disease Relevance 0 Pain Relevance 0
Synthesis of Mini-B (MB), Super Mini-B (S-MB) and SP-B(1-8) Peptides
Gene_expression (Synthesis) of Super
13) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2805716 Disease Relevance 0 Pain Relevance 0

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