INT148471

Context Info Confidence 0.38 First Reported 2008 Last Reported 2008 Negated 1 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.29 Pain Relevance 0.69

transmembrane transport (Trpa1)

Anatomy Link Frequency DRG 2 Trpa1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat dorsal root ganglion 3 98.68 qutenza 8 98.40

Disease Link Frequency Relevance Heat Ganglion Cysts 3 98.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Gene expression analysis for various thermo-sensitive transient receptor potential (TRP) channels indicated marked reductions in the mRNA levels of TRPV1 (70%), TRPM8 (46%) and TRPA1 (64%), but not of TRPV2, in the DRG of capsaicin-treated rats compared with those in the control rats.

Negative_regulation (reductions) of Neg (not) Transcription (levels) of TRPA1 in DRG associated with dorsal root ganglion and qutenza

1) Confidence 0.38 Published 2008 Journal J. Biochem. Section Abstract Doc Link 18079164 Disease Relevance 0.29 Pain Relevance 0.69

General Comments

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