INT148494

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Context Info
Confidence 0.40
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 5.97
Pain Relevance 2.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

embryo development (Cdk5) cytoplasm (Cdk5) cytosol (Cdk5)
nucleocytoplasmic transport (Cdk5) cell death (Cdk5) nucleolus (Cdk5)
Anatomy Link Frequency
adult mouse 1
Cdk5 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 2 100.00 Very High Very High Very High
Physical dependence 4 99.68 Very High Very High Very High
ischemia 48 99.40 Very High Very High Very High
tolerance 8 98.70 Very High Very High Very High
Analgesic 7 98.50 Very High Very High Very High
Morphine 6 98.44 Very High Very High Very High
narcan 2 97.98 Very High Very High Very High
Eae 6 97.44 Very High Very High Very High
analgesia 2 97.12 Very High Very High Very High
Pain 1 92.80 High High
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 10 99.76 Very High Very High Very High
Drug Dependence 4 99.68 Very High Very High Very High
Death 113 99.44 Very High Very High Very High
Apoptosis 148 99.12 Very High Very High Very High
Convulsion 136 99.10 Very High Very High Very High
Targeted Disruption 159 96.64 Very High Very High Very High
Injury 24 96.56 Very High Very High Very High
Sclerosis 4 96.48 Very High Very High Very High
Pain 1 92.80 High High
Drug Induced Neurotoxicity 6 91.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CDK5 is associated with cerebral ischemia.
CDK5 Binding (associated) of associated with cv general 4 under development and ischemia
1) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920814 Disease Relevance 0.90 Pain Relevance 0.21
Analysis of the bound proteins by SDS-PAGE followed by silver staining and Western blotting showed that (S)-roscovitine preferentially bound Erk2 and CDK5 in the adult mouse brain (Figure 3B).
CDK5 Binding (bound) of in adult mouse
2) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920814 Disease Relevance 0.26 Pain Relevance 0.04
There may be common mechanistic features between loss of Cdk5 and diversion of Cdk5 to form a complex with p25.
Cdk5 Binding (complex) of
3) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.51 Pain Relevance 0.12
Interestingly, increased seizure susceptibility correlated with lethality as loss of Cdk5 for 8 weeks and daily handling resulted in 40% mortality (Figure 5A, bottom; Table 1).
Cdk5 Binding (loss) of associated with convulsion
4) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.32 Pain Relevance 0
Morphine-induced analgesic tolerance, locomotor sensitization and physical dependence do not require modification of mu opioid receptor, cdk5 and adenylate cyclase activity.
cdk5 Neg (not) Binding (modification) of associated with physical dependence, analgesic, mu opioid receptor, tolerance and morphine
5) Confidence 0.35 Published 2008 Journal Neuropharmacology Section Title Doc Link 18082850 Disease Relevance 0.51 Pain Relevance 1.85
CDK5 is inactive in its monomeric form and needs p35 for activation, but when cells undergo oxidative injury or treatment with A?
CDK5 Binding (inactive) of associated with injury
6) Confidence 0.11 Published 2009 Journal Microb Cell Fact Section Body Doc Link PMC2674406 Disease Relevance 0.58 Pain Relevance 0
Inhibition of cdk5 or calpain activity reduced cell death in A?
cdk5 Binding (activity) of associated with death
7) Confidence 0.05 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.90 Pain Relevance 0.09

General Comments

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