INT148862

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 3
Total Number 3
Disease Relevance 1.40
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
peripheral nerve 1
Hcn4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Analgesic 3 98.76 Very High Very High Very High
allodynia 4 98.56 Very High Very High Very High
anticonvulsant 1 98.46 Very High Very High Very High
Gabapentin 3 98.08 Very High Very High Very High
Peripheral nerve injury 2 97.92 Very High Very High Very High
intrathecal 3 97.60 Very High Very High Very High
Neuropathic pain 5 95.40 Very High Very High Very High
Thermal hyperalgesia 2 93.32 High High
Peripheral sensitization 1 91.72 High High
dorsal root ganglion 5 88.92 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 9 98.56 Very High Very High Very High
Nervous System Injury 2 97.48 Very High Very High Very High
Hyperalgesia 2 93.32 High High
Ganglion Cysts 5 88.44 High High
Injury 2 86.64 High High
Hypertrophy 6 66.16 Quite High
Obesity 3 50.00 Quite Low
Fibrosis 5 14.72 Low Low
Aging 11 5.00 Very Low Very Low Very Low
Heart Rate Under Development 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It follows, therefore, that there was an age-dependent increase of Nav1.5-negative/HCN4-positive/Cx43-negative tissue.
Positive_regulation (increase) of HCN4
1) Confidence 0.47 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.07 Pain Relevance 0.18
BACKGROUND AND OBJECTIVE: Gabapentin, an anticonvulsant with analgesic effect, has been reported to be an activator of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.
Positive_regulation (activator) of hyperpolarization-activated cyclic nucleotide-gated associated with analgesic, anticonvulsant and gabapentin
2) Confidence 0.41 Published 2009 Journal Eur J Anaesthesiol Section Abstract Doc Link 19322095 Disease Relevance 0 Pain Relevance 0.54
Axonal accumulation of hyperpolarization-activated cyclic nucleotide-gated cation channels contributes to mechanical allodynia after peripheral nerve injury in rat.
Positive_regulation (accumulation) of hyperpolarization-activated cyclic nucleotide-gated cation in peripheral nerve associated with nervous system injury, allodynia and peripheral nerve injury
3) Confidence 0.35 Published 2008 Journal Pain Section Title Doc Link 18179873 Disease Relevance 1.33 Pain Relevance 1.01

General Comments

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