INT149029

Context Info Confidence 0.36 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

Golgi apparatus (Tjp1) plasma membrane (Tjp1) nucleus (Tjp1) cytoplasm (Tjp1)

Tjp1 (Mus musculus)

Pain Link Frequency Relevance Heat spastic colon 1 5.00

Disease Link Frequency Relevance Heat Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 2 50.00 Functional Bowel Disorder 1 5.00 Diarrhoea 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In mice, colonic exposure to supernatants from IBS-D patients resulted in a rapid increase in the phosphorylation of myosin light chain and delayed redistribution of ZO-1 in colonocytes.

Positive_regulation (increase) of Negative_regulation (redistribution) of ZO-1

1) Confidence 0.36 Published 2008 Journal Gut Section Body Doc Link 18194983 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.