INT149239

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Context Info
Confidence 0.66
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 3.08
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc12a1) transmembrane transport (Slc12a1)
Anatomy Link Frequency
duct 1
kidney 1
Slc12a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 5 99.20 Very High Very High Very High
withdrawal 1 92.68 High High
cINOD 6 86.56 High High
anesthesia 9 25.00 Low Low
Disease Link Frequency Relevance Heat
Kidney Stones 64 99.82 Very High Very High Very High
Polyuria 3 99.62 Very High Very High Very High
Diabetes Insipidus 7 98.74 Very High Very High Very High
Nephrocalcinosis 1 91.16 High High
INFLAMMATION 2 86.00 High High
Renal Failure 3 84.08 Quite High
Acid Base Imbalance 1 81.24 Quite High
Natriuresis 1 80.32 Quite High
Bartter Syndrome 4 78.40 Quite High
Sepsis 2 78.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our experiment, high calcium diet and vitamin D3 decreased protein abundance of TRPV5, NHE3, SGLT1, and NKCC2, resulting in severe hypercalciuria and the expression of TRPV5, NHE3, and NKCC2 was not restored by HCTZ administration.
Gene_expression (expression) of NKCC2 associated with kidney stones
1) Confidence 0.66 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.19 Pain Relevance 0
We performed a preliminary study with immunohistochemistry of NKCC2 and NCC and there was no difference in the expression of NKCC2 and NCC between groups.
Gene_expression (expression) of NKCC2
2) Confidence 0.66 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.19 Pain Relevance 0
To assess the effect of thiazides on the transporters participating in the passive and active calcium reabsorption under severe hypercalciuric condition, the expression of NHE3 and SGLT1 on the PT, NKCC2 on the TAL, and TRPV5 and calbindin-D28K on the DCT was analyzed.


Spec (analyzed) Gene_expression (expression) of NKCC2
3) Confidence 0.66 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.28 Pain Relevance 0
Because renal prostaglandins are derived largely from cyclooxygenase-2 (COX-2), we hypothesized that treatment of NDI with a COX-2 inhibitor may relieve polyuria through increased expression of Na-K-2Cl cotransporter type 2 (NKCC2) in the thick ascending limb and aquaporin-2 (AQP2) in the collecting duct.
Gene_expression (expression) of NKCC2 in duct associated with polyuria, diabetes insipidus and cox-2 inhibitor
4) Confidence 0.66 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18216147 Disease Relevance 0.75 Pain Relevance 0.32
Next, we aimed to examine the changes of iNOS expression and activated macrophage infiltration in the kidney and the effects of iNOS inhibition on AQP2 and NKCC2 expression in LPS rats.
Gene_expression (expression) of NKCC2 in kidney
5) Confidence 0.50 Published 2009 Journal Nephrol. Dial. Transplant. Section Abstract Doc Link 19193739 Disease Relevance 0.46 Pain Relevance 0
Expression of NHE3, SGLT1, and NKCC2 mRNA was significantly decreased in the high Ca-vitamin D group, which increased when HCTZ was administered. mRNA expression results are summarized in Table 3.


Gene_expression (Expression) of NKCC2
6) Confidence 0.22 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.13 Pain Relevance 0
Direct sequencing of NKCC2, ROMK, ClC-Kb, and NCCT in this patient disclosed a novel homozygous missense mutation (GGG to GAG, G470E) in CLCNKB.
Gene_expression (sequencing) of NKCC2
7) Confidence 0.10 Published 2009 Journal Eur. J. Pediatr. Section Abstract Doc Link 19050915 Disease Relevance 1.08 Pain Relevance 0.27

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