INT149491

Context Info Confidence 0.40 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.37 Pain Relevance 1.76

extracellular region (PNOC, CD14) extracellular space (CD14) signal transduction (PNOC) plasma membrane (CD14)

Anatomy Link Frequency monocytes 4 PNOC (Homo sapiens) CD14 (Homo sapiens)

Pain Link Frequency Relevance Heat orphanin 14 100.00 chemokine 12 100.00 Inflammation 8 94.04 Central nervous system 6 79.12 Opioid 2 71.80 agonist 2 54.16 antagonist 2 53.12

Disease Link Frequency Relevance Heat INFLAMMATION 6 94.04 Disease 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our results also demonstrate that nociceptin can suppress the production of CCL2/MCP-1 and CCL5/RANTES chemokine protein in both primary CD14(+) human monocytes and monocyte-like cell lines.

nociceptin Negative_regulation (suppress) of Gene_expression (production) of CD14 in monocytes associated with chemokine and orphanin

1) Confidence 0.40 Published 2008 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18247127 Disease Relevance 0.18 Pain Relevance 0.88

Our results also demonstrate that nociceptin can suppress the production of CCL2/MCP-1 and CCL5/RANTES chemokine protein in both primary CD14(+) human monocytes and monocyte-like cell lines.

nociceptin Negative_regulation (suppress) of in monocyte Gene_expression (production) of CD14 in monocytes associated with chemokine and orphanin

2) Confidence 0.14 Published 2008 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18247127 Disease Relevance 0.18 Pain Relevance 0.88

General Comments

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