INT149656

Context Info Confidence 0.38 First Reported 2005 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 2.36 Pain Relevance 1.02

plasma membrane (Slc12a2)

Slc12a2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat anticonvulsant 5 97.04 Inflammation 8 96.60 Spinal cord 6 95.40 IPN 2 89.16 Hyperalgesia 2 84.12 intrathecal 1 84.00 allodynia 1 83.44 gABA 36 77.36 Stimulus evoked pain 1 75.00 Dorsal horn neuron 1 75.00

Disease Link Frequency Relevance Heat Targeted Disruption 3 99.48 Chronic Renal Failure 248 99.20 INFLAMMATION 5 96.60 Inflammatory Pain 3 89.16 Neuropathic Pain 3 85.20 Hyperalgesia 2 84.12 Convulsion 30 78.44 Hypersensitivity 2 75.00 Syndrome 1 60.40 Epilepsy 22 59.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our results suggest that the expression of KCC2, but not that of NKCC1, was significantly reduced in CFA-injected rats.

Negative_regulation (reduced) of Gene_expression (expression) of NKCC1

1) Confidence 0.38 Published 2008 Journal Neuroscience Section Abstract Doc Link 18262726 Disease Relevance 0.95 Pain Relevance 0.86

Its efficacy dropped though in older ages, probably due to the decreased expression of NKCC1.

Negative_regulation (decreased) of Gene_expression (expression) of NKCC1

2) Confidence 0.21 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0.54 Pain Relevance 0.17

In contrast, mice lacking NHE3 showed decreased expression of BSC-1 and sodium wasting (33), however they also had decreased SNGFR in contrast to CRF (34).

Negative_regulation (decreased) of Gene_expression (expression) of BSC-1 associated with chronic renal failure

3) Confidence 0.12 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.43 Pain Relevance 0

The observed decrease in BSC-1 abundance in the NHE3 knockout mice is unexplained based on current knowledge regarding the regulation of these transporters and further investigation is needed to address this.

Negative_regulation (decrease) of Gene_expression (abundance) of BSC-1 associated with targeted disruption

4) Confidence 0.07 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.43 Pain Relevance 0

General Comments

This test has worked.