INT14976

Context Info Confidence 0.24 First Reported 1986 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 0.75 Pain Relevance 0.86

endosome (Adrb2) plasma membrane (Adrb2) nucleus (Adrb2) cytoplasm (Adrb2) signal transducer activity (Adrb2)

Anatomy Link Frequency nerve 1 Adrb2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Clonidine 7 100.00 agonist 4 99.96 guanethidine 1 96.24 Catecholamine 2 93.60 antagonist 4 87.20 Intracerebroventricular 4 84.80 beta blocker 1 76.28 anesthesia 1 74.08 Central nervous system 2 30.60

Disease Link Frequency Relevance Heat Stress 8 97.76 Ocular Hypertension 6 95.60 Hypertension 2 75.00 Glaucoma 2 75.00 Hypotension 1 47.40 Mydriatic 1 41.04 Cataract 1 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Conversely, selective beta2 adrenergic receptor blockade did not affect MCFP responses to BMI.

Negative_regulation (blockade) of beta2 adrenergic receptor

1) Confidence 0.24 Published 2006 Journal Brain Res. Section Abstract Doc Link 16473331 Disease Relevance 0 Pain Relevance 0.17

These results indicate that the increased renal sympathetic nerve activity and antinatriuresis resulting from environmental stress in conscious SHR can be prevented by pharmacological stimulation of central alpha 2-adrenergic receptors or by blockade of central beta 2-adrenergic receptors.

Negative_regulation (blockade) of beta 2-adrenergic in nerve associated with stress

2) Confidence 0.22 Published 1986 Journal Hypertension Section Abstract Doc Link 3002980 Disease Relevance 0.48 Pain Relevance 0.34

Apraclonidine hydrochloride is a derivative of clonidine hydrochloride, an alpha 2-adrenergic agonist.

Negative_regulation (derivative) of 2-adrenergic associated with agonist and clonidine

3) Confidence 0.00 Published 1991 Journal Drugs Section Abstract Doc Link 1711957 Disease Relevance 0.28 Pain Relevance 0.35

General Comments

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