INT149974

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.52
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NR4A2) signal transduction (NR4A2) nucleus (NR4A2)
cytoplasm (NR4A2)
Anatomy Link Frequency
neuronal stem cells 2
NR4A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 2 99.60 Very High Very High Very High
Dopamine 86 98.72 Very High Very High Very High
midbrain 31 98.60 Very High Very High Very High
agonist 2 58.28 Quite High
Substantia nigra 10 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
Action potential 4 5.00 Very Low Very Low Very Low
gABA 3 5.00 Very Low Very Low Very Low
dexamethasone 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 4 82.96 Quite High
Apoptosis 10 79.92 Quite High
Death 16 63.44 Quite High
Disease 19 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 8 5.00 Very Low Very Low Very Low
Repression 5 5.00 Very Low Very Low Very Low
Mucocutaneous Lymph Node Syndrome 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Shock 3 5.00 Very Low Very Low Very Low
Asthma 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Melanocortin-1 receptor signaling markedly induces the expression of the NR4A nuclear receptor subgroup in melanocytic cells.
Positive_regulation (induces) of Gene_expression (expression) of NR4A nuclear receptor associated with melanocortin 1 receptor
1) Confidence 0.41 Published 2008 Journal J. Biol. Chem. Section Title Doc Link 18292087 Disease Relevance 0.32 Pain Relevance 0.23
Western blot analysis confirmed expression of the MAP2, Nuclear receptor 1 (Nurr1), and TH proteins (Fig. 5B).
Positive_regulation (confirmed) of Gene_expression (expression) of Nurr1
2) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.28
Thus, higher yields of dopaminergic neurons were obtained when neuronal stem cells overexpressing Nurr1 (Grothe et al., 2004) or monkey ESCs (Takagi et al., 2005) were differentiated in the presence of FGF-20.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of Nurr1 in neuronal stem cells
3) Confidence 0.09 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525922 Disease Relevance 0.13 Pain Relevance 0.08
In addition, Nurr2 is generated by alternative splicing in exon 1 and 2, resulting in a shorter N-terminal region, as well.
Positive_regulation (generated) of Gene_expression (generated) of Nurr2
4) Confidence 0.06 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.08 Pain Relevance 0

General Comments

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