INT150001

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.71
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Agps) plasma membrane (Agps) peroxisome (Agps)
Anatomy Link Frequency
liver 1
kidney 1
Agps (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 28 100.00 Very High Very High Very High
depression 42 99.24 Very High Very High Very High
Dismenorea 3 90.64 High High
Lasting pain 3 89.56 High High
fluoxetine 2 78.40 Quite High
Endep 2 74.12 Quite High
Disease Link Frequency Relevance Heat
Depression 66 99.24 Very High Very High Very High
Anxiety Disorder 9 99.12 Very High Very High Very High
Panic Disorder 9 98.64 Very High Very High Very High
Dementia 3 96.96 Very High Very High Very High
Reprotox - General 1 3 90.64 High High
Pain 3 89.56 High High
Sleep Disorders 3 88.08 High High
Depressive Disorder 33 85.04 High High
Phobia 6 83.36 Quite High
Disease 3 56.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, the purpose of TDM for new-generation ADs leads more to the monitoring of patient compliance and special patient groups such as the elderly, patients with liver and kidney impairment, patients with poor metabolism by CYP 450 and comedication with inhibitors and inducers of those enzymes.
Positive_regulation (leads) of ADs in kidney associated with antidepressant
1) Confidence 0.43 Published 2008 Journal Crit Rev Clin Lab Sci Section Abstract Doc Link 18293180 Disease Relevance 0 Pain Relevance 0.55
The pharmaceutical companies' marketing of ADs is another powerful incentive to increase the use of ADs.
Positive_regulation (increase) of ADs
2) Confidence 0.19 Published 2005 Journal BMC Fam Pract Section Body Doc Link PMC1180707 Disease Relevance 0.16 Pain Relevance 0.04
Thus, high sales levels correlated positively with a high evaluation of ADs' effectiveness in depression and panic disorders and were inversely correlated with the degree of appreciation of psychotherapy-based treatments.
Positive_regulation (evaluation) of ADs associated with panic disorder and depression
3) Confidence 0.19 Published 2005 Journal BMC Fam Pract Section Body Doc Link PMC1180707 Disease Relevance 0.80 Pain Relevance 0.17
The responders' judgments on the statement that ADs are effective for the treatment of anxiety and behavioural disturbances in patients with dementia were distributed evenly from agree not at all to completely agreement (Fig. 4).
Positive_regulation (effective) of ADs associated with dementia and anxiety disorder
4) Confidence 0.18 Published 2005 Journal BMC Fam Pract Section Body Doc Link PMC1180707 Disease Relevance 0.75 Pain Relevance 0.24
Therefore, the purpose of TDM for new-generation ADs leads more to the monitoring of patient compliance and special patient groups such as the elderly, patients with liver and kidney impairment, patients with poor metabolism by CYP 450 and comedication with inhibitors and inducers of those enzymes.
Positive_regulation (leads) of ADs in liver associated with antidepressant
5) Confidence 0.15 Published 2008 Journal Crit Rev Clin Lab Sci Section Abstract Doc Link 18293180 Disease Relevance 0 Pain Relevance 0.55

General Comments

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