INT150156

From wiki-pain
Revision as of 13:06, 21 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.20
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 13
Disease Relevance 4.07
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DOA) plasma membrane (HLA-DOA)
Anatomy Link Frequency
dendritic cells 4
leukocyte 2
T cell 2
macrophages 1
B-cells 1
HLA-DOA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 6 98.72 Very High Very High Very High
cytokine 16 98.20 Very High Very High Very High
Arthritis 1 87.80 High High
spinal inflammation 3 87.12 High High
cINOD 22 84.96 Quite High
Multiple sclerosis 49 81.76 Quite High
Osteoarthritis 1 63.84 Quite High
headache 7 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 28 99.80 Very High Very High Very High
INFLAMMATION 7 98.72 Very High Very High Very High
Disease 80 97.68 Very High Very High Very High
Sprains And Strains 133 92.24 High High
Stress 7 89.28 High High
Arthritis 1 87.80 High High
Seronegative Spondarthritis 4 87.12 High High
Pox Virus Infection 14 86.56 High High
Infection 57 85.36 High High
Colon Cancer 9 84.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AD is characterised by chronic inflammation and altered immune function, including activation of immunocompetent glia expressing high levels of human leukocyte antigen (HLA) molecules, complement and pro-inflammatory cytokines [1].
Positive_regulation (levels) of Gene_expression (expressing) of HLA in leukocyte associated with inflammation, disease and cytokine
1) Confidence 0.20 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764414 Disease Relevance 0.86 Pain Relevance 0.23
Levels were higher in HLA B-27 negative patients (p = 0.02).
Positive_regulation (higher) of Neg (negative) Gene_expression (negative) of HLA
2) Confidence 0.04 Published 2009 Journal Clin. Rheumatol. Section Abstract Doc Link 18827961 Disease Relevance 0.53 Pain Relevance 0.28
Suggested HLA class I restriction
Positive_regulation (Suggested) of Gene_expression (restriction) of HLA
3) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0.06 Pain Relevance 0
Despite the complex epitope recognition pattern observed, we hypothesised that all of the newly identified WNV epitopes will induce a CTL response in all individuals carrying the restricting HLA class I allele, if the individuals were to be immunised with the epitopes.
Positive_regulation (restricting) of Gene_expression (allele) of HLA
4) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0.33 Pain Relevance 0
This result reflects that we started out by predicting epitopes restricted by the 12 HLA class I alleles that represent the major class I supertypes [20], but tested the predicted epitopes in all patients, regardless of whether the patients carried any of these specific 12 HLA class I supertype representative alleles or, for example, another HLA class I allele belonging to the same supertype.
Positive_regulation (belonging) of Gene_expression (allele) of HLA
5) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0 Pain Relevance 0
Unlike the results of our recent study identifying WNV CD8+ T cell epitopes, where reactivity to four dominating epitopes were found in almost all patients expressing the restricting HLA class I allele [10], the CD8+ T cell epitopes identified in the present study maximally induced response in about 25% of patients bearing the appropriate HLA.
Positive_regulation (restricting) of Gene_expression (expressing) of HLA in T cell
6) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0.18 Pain Relevance 0
The complex epitope recognition pattern in the WNV infected patients showed that not all peptides that induce a CTL response in one patient do so in all patients expressing the restricting HLA class I allele.
Positive_regulation (restricting) of Gene_expression (expressing) of HLA
7) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0.18 Pain Relevance 0
Note that 17 of the peptides are predicted to be restricted by more than one HLA class I allele, resulting in a total of 175 unique peptides.
Positive_regulation (one) of Gene_expression (allele) of HLA
8) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0.09 Pain Relevance 0
None of the identified epitopes induced a response in all patients expressing the predicted restricting HLA class I allele.
Positive_regulation (restricting) of Gene_expression (expressing) of HLA
9) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0.14 Pain Relevance 0
Upon addition of 1,25-dihydroxyvitamin D3, there was a 1.3 fold increase in the expression of HLA-DRB1 in PGF cells (P?
Positive_regulation (increase) of Gene_expression (expression) of HLA
10) Confidence 0.02 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2627899 Disease Relevance 0.27 Pain Relevance 0.07
This study evaluates HLA gene expression and tumor infiltration by B-cells, macrophages, dendritic cells, T-helper and cytotoxic T-lymphocytes in response to short-term preoperative treatment with cyclooxygenase inhibitors.
Positive_regulation (evaluates) of Gene_expression (expression) of HLA gene in dendritic cells associated with cancer
11) Confidence 0.00 Published 2008 Journal Cancer Immun. Section Abstract Doc Link 18307280 Disease Relevance 0.48 Pain Relevance 0.30
This study evaluates HLA gene expression and tumor infiltration by B-cells, macrophages, dendritic cells, T-helper and cytotoxic T-lymphocytes in response to short-term preoperative treatment with cyclooxygenase inhibitors.
Positive_regulation (evaluates) of in macrophages Gene_expression (expression) of HLA gene in dendritic cells associated with cancer
12) Confidence 0.00 Published 2008 Journal Cancer Immun. Section Abstract Doc Link 18307280 Disease Relevance 0.48 Pain Relevance 0.30
This study evaluates HLA gene expression and tumor infiltration by B-cells, macrophages, dendritic cells, T-helper and cytotoxic T-lymphocytes in response to short-term preoperative treatment with cyclooxygenase inhibitors.
Positive_regulation (evaluates) of in B-cells Gene_expression (expression) of HLA gene in dendritic cells associated with cancer
13) Confidence 0.00 Published 2008 Journal Cancer Immun. Section Abstract Doc Link 18307280 Disease Relevance 0.48 Pain Relevance 0.30

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox