INT150156

Context Info Confidence 0.20 First Reported 2006 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 7 Total Number 13 Disease Relevance 4.07 Pain Relevance 1.50

endosome (HLA-DOA) plasma membrane (HLA-DOA)

Anatomy Link Frequency dendritic cells 4 leukocyte 2 T cell 2 macrophages 1 B-cells 1 HLA-DOA (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 6 98.72 cytokine 16 98.20 Arthritis 1 87.80 spinal inflammation 3 87.12 cINOD 22 84.96 Multiple sclerosis 49 81.76 Osteoarthritis 1 63.84 headache 7 5.00 Central nervous system 2 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Cancer 28 99.80 INFLAMMATION 7 98.72 Disease 80 97.68 Sprains And Strains 133 92.24 Stress 7 89.28 Arthritis 1 87.80 Seronegative Spondarthritis 4 87.12 Pox Virus Infection 14 86.56 Infection 57 85.36 Colon Cancer 9 84.16

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

AD is characterised by chronic inflammation and altered immune function, including activation of immunocompetent glia expressing high levels of human leukocyte antigen (HLA) molecules, complement and pro-inflammatory cytokines [1].

Positive_regulation (levels) of Gene_expression (expressing) of HLA in leukocyte associated with inflammation, disease and cytokine

1) Confidence 0.20 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764414 Disease Relevance 0.86 Pain Relevance 0.23

Levels were higher in HLA B-27 negative patients (p = 0.02).

Positive_regulation (higher) of Neg (negative) Gene_expression (negative) of HLA

2) Confidence 0.04 Published 2009 Journal Clin. Rheumatol. Section Abstract Doc Link 18827961 Disease Relevance 0.53 Pain Relevance 0.28

Suggested HLA class I restriction

Positive_regulation (Suggested) of Gene_expression (restriction) of HLA

3) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0.06 Pain Relevance 0

Despite the complex epitope recognition pattern observed, we hypothesised that all of the newly identified WNV epitopes will induce a CTL response in all individuals carrying the restricting HLA class I allele, if the individuals were to be immunised with the epitopes.

Positive_regulation (restricting) of Gene_expression (allele) of HLA

4) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0.33 Pain Relevance 0

This result reflects that we started out by predicting epitopes restricted by the 12 HLA class I alleles that represent the major class I supertypes [20], but tested the predicted epitopes in all patients, regardless of whether the patients carried any of these specific 12 HLA class I supertype representative alleles or, for example, another HLA class I allele belonging to the same supertype.

Positive_regulation (belonging) of Gene_expression (allele) of HLA

5) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0 Pain Relevance 0

Unlike the results of our recent study identifying WNV CD8+ T cell epitopes, where reactivity to four dominating epitopes were found in almost all patients expressing the restricting HLA class I allele [10], the CD8+ T cell epitopes identified in the present study maximally induced response in about 25% of patients bearing the appropriate HLA.

Positive_regulation (restricting) of Gene_expression (expressing) of HLA in T cell

6) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0.18 Pain Relevance 0

The complex epitope recognition pattern in the WNV infected patients showed that not all peptides that induce a CTL response in one patient do so in all patients expressing the restricting HLA class I allele.

Positive_regulation (restricting) of Gene_expression (expressing) of HLA

7) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0.18 Pain Relevance 0

Note that 17 of the peptides are predicted to be restricted by more than one HLA class I allele, resulting in a total of 175 unique peptides.

Positive_regulation (one) of Gene_expression (allele) of HLA

8) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0.09 Pain Relevance 0

None of the identified epitopes induced a response in all patients expressing the predicted restricting HLA class I allele.

Positive_regulation (restricting) of Gene_expression (expressing) of HLA

9) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0.14 Pain Relevance 0

Upon addition of 1,25-dihydroxyvitamin D3, there was a 1.3 fold increase in the expression of HLA-DRB1 in PGF cells (P?

Positive_regulation (increase) of Gene_expression (expression) of HLA

10) Confidence 0.02 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2627899 Disease Relevance 0.27 Pain Relevance 0.07

This study evaluates HLA gene expression and tumor infiltration by B-cells, macrophages, dendritic cells, T-helper and cytotoxic T-lymphocytes in response to short-term preoperative treatment with cyclooxygenase inhibitors.

Positive_regulation (evaluates) of Gene_expression (expression) of HLA gene in dendritic cells associated with cancer

11) Confidence 0.00 Published 2008 Journal Cancer Immun. Section Abstract Doc Link 18307280 Disease Relevance 0.48 Pain Relevance 0.30

This study evaluates HLA gene expression and tumor infiltration by B-cells, macrophages, dendritic cells, T-helper and cytotoxic T-lymphocytes in response to short-term preoperative treatment with cyclooxygenase inhibitors.

Positive_regulation (evaluates) of in macrophages Gene_expression (expression) of HLA gene in dendritic cells associated with cancer

12) Confidence 0.00 Published 2008 Journal Cancer Immun. Section Abstract Doc Link 18307280 Disease Relevance 0.48 Pain Relevance 0.30

This study evaluates HLA gene expression and tumor infiltration by B-cells, macrophages, dendritic cells, T-helper and cytotoxic T-lymphocytes in response to short-term preoperative treatment with cyclooxygenase inhibitors.

Positive_regulation (evaluates) of in B-cells Gene_expression (expression) of HLA gene in dendritic cells associated with cancer

13) Confidence 0.00 Published 2008 Journal Cancer Immun. Section Abstract Doc Link 18307280 Disease Relevance 0.48 Pain Relevance 0.30

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