INT150191

Context Info Confidence 0.34 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.14 Pain Relevance 1.16

nucleoplasm (FOS) aging (FOS) nucleolus (FOS) nucleus (FOS)

Anatomy Link Frequency CPA 2 CEACAM3 (Homo sapiens) FOS (Homo sapiens)

Pain Link Frequency Relevance Heat Morphine 4 91.92 withdrawal 3 91.00 narcan 4 90.04 amygdala 3 87.20 nMDA receptor antagonist 1 86.16 addiction 6 83.80 opiate 5 78.48 antagonist 3 76.32 Glutamate receptor 1 66.88 Glutamate 1 60.16

Disease Link Frequency Relevance Heat Opiate Addiction 1 78.92 Substance Withdrawal Syndrome 1 58.92 Morphine Dependence 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Findings showed that CeA displayed significant increase in c-Fos expression in the acquisition of CPA.

CeA Positive_regulation (increase) of Gene_expression (expression) of c-Fos in CPA

1) Confidence 0.34 Published 2008 Journal Yakugaku Zasshi Section Abstract Doc Link 18311059 Disease Relevance 0.14 Pain Relevance 1.16

General Comments

This test has worked.