INT150275

From wiki-pain
Revision as of 12:45, 20 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.68
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.57
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP8) extracellular space (MMP8) extracellular region (MMP8)
proteinaceous extracellular matrix (MMP8)
Anatomy Link Frequency
brain 1
sensory nerves 1
neutrophils 1
MMP8 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 11 100.00 Very High Very High Very High
Inflammation 183 99.14 Very High Very High Very High
Neuropeptide 2 97.68 Very High Very High Very High
Pain 3 95.92 Very High Very High Very High
substance P 2 91.20 High High
cva 7 89.84 High High
Inflammatory mediators 4 80.32 Quite High
rheumatoid arthritis 1 75.92 Quite High
cINOD 2 70.96 Quite High
ischemia 1 63.60 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 194 99.14 Very High Very High Very High
Adhesions 1 98.72 Very High Very High Very High
Dengue Hemorrhagic Fever 205 98.14 Very High Very High Very High
Hemorrhage 75 97.72 Very High Very High Very High
Stroke 6 93.92 High High
Pressure And Volume Under Development 1 90.40 High High
Pain 3 85.08 High High
Brain Injury 1 83.60 Quite High
Chorioamnionitis 16 79.60 Quite High
Atherosclerosis 2 76.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pro-inflammatory neuropeptides released by sensory nerves coordinate the activities of the immuno-effector cells and may influence the secretion of MMP-8.
Localization (secretion) of MMP-8 in sensory nerves associated with metalloproteinase and neuropeptide
1) Confidence 0.68 Published 2008 Journal Acta Odontol. Scand. Section Abstract Doc Link 18320414 Disease Relevance 0.34 Pain Relevance 0.75
A putative neutrophil origin of this gene expression pattern is however supported by the over-expression in DSS patients blood cells of transcripts encoding other neutrophil-related molecules such as the MMP8 matrix metalloprotease, CEACAM-6, CEACAM-8 and CD99L2 adhesion molecules (Tables 4 and S2) involved in the recruitment of neutrophils to vascular endothelia.
Localization (metalloprotease) of MMP8 in neutrophils associated with dengue hemorrhagic fever and adhesions
2) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 1.16 Pain Relevance 0.22
Although the exact cellular source of MMPs remains unknown, brain endothelium, astrocytes, neurons, and inflammatory-activated cells, such as neutrophils, may release MMP-2, MMP-3, MMP-8, MMP-9, MMP-10, and/or MMP-13.
Localization (release) of MMP-8 in brain associated with inflammation and metalloproteinase
3) Confidence 0.47 Published 2010 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 20955435 Disease Relevance 1.07 Pain Relevance 0.52
Immunoassays for interleukin-6 (IL-6) and matrix metalloprotease-8 (MMP-8)
Localization (metalloprotease) of MMP-8
4) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2315798 Disease Relevance 0.51 Pain Relevance 0.13
ELISA for human IL-6 (Pierce-Endogen, Rockford, IL) and MMP-8 (R&D Systems, Minneapolis, MN) were performed in duplicate by investigators unaware of clinical outcomes.
Localization (performed) of MMP-8
5) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2315798 Disease Relevance 0.49 Pain Relevance 0.12

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox