INT150275

Context Info Confidence 0.68 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 3.57 Pain Relevance 1.74

peptidase activity (MMP8) extracellular space (MMP8) extracellular region (MMP8) proteinaceous extracellular matrix (MMP8)

Anatomy Mention Frequency brain 1 sensory nerves 1 neutrophils 1 MMP8 (Homo sapiens)

Pain Term Frequency Confidence Heat metalloproteinase 11 100.00 Inflammation 183 99.14 Neuropeptide 2 97.68 Pain 3 95.92 substance P 2 91.20 cva 7 89.84 Inflammatory mediators 4 80.32 rheumatoid arthritis 1 75.92 cINOD 2 70.96 ischemia 1 63.60

Disease Term Frequency Confidence Heat INFLAMMATION 194 99.14 Adhesions 1 98.72 Dengue Hemorrhagic Fever 205 98.14 Hemorrhage 75 97.72 Stroke 6 93.92 Pressure And Volume Under Development 1 90.40 Pain 3 85.08 Brain Injury 1 83.60 Chorioamnionitis 16 79.60 Atherosclerosis 2 76.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The pro-inflammatory neuropeptides released by sensory nerves coordinate the activities of the immuno-effector cells and may influence the secretion of MMP-8.

Localization (secretion) of MMP-8 in sensory nerves associated with metalloproteinase and neuropeptide

1) Confidence 0.68 Published 2008 Journal Acta Odontol. Scand. Section Abstract Doc Link 18320414 Disease Relevance 0.34 Pain Relevance 0.75

A putative neutrophil origin of this gene expression pattern is however supported by the over-expression in DSS patients blood cells of transcripts encoding other neutrophil-related molecules such as the MMP8 matrix metalloprotease, CEACAM-6, CEACAM-8 and CD99L2 adhesion molecules (Tables 4 and S2) involved in the recruitment of neutrophils to vascular endothelia.

Localization (metalloprotease) of MMP8 in neutrophils associated with dengue hemorrhagic fever and adhesions

2) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 1.16 Pain Relevance 0.22

Although the exact cellular source of MMPs remains unknown, brain endothelium, astrocytes, neurons, and inflammatory-activated cells, such as neutrophils, may release MMP-2, MMP-3, MMP-8, MMP-9, MMP-10, and/or MMP-13.

Localization (release) of MMP-8 in brain associated with inflammation and metalloproteinase

3) Confidence 0.47 Published 2010 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 20955435 Disease Relevance 1.07 Pain Relevance 0.52

Immunoassays for interleukin-6 (IL-6) and matrix metalloprotease-8 (MMP-8)

Localization (metalloprotease) of MMP-8

4) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2315798 Disease Relevance 0.51 Pain Relevance 0.13

ELISA for human IL-6 (Pierce-Endogen, Rockford, IL) and MMP-8 (R&D Systems, Minneapolis, MN) were performed in duplicate by investigators unaware of clinical outcomes.

Localization (performed) of MMP-8

5) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2315798 Disease Relevance 0.49 Pain Relevance 0.12

General Comments

This test has worked.