INT150290

Context Info Confidence 0.10 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.53 Pain Relevance 0.38

extracellular space (Calca) extracellular region (Calca) nucleus (Calca) intracellular (Calca) kinase activity (Grk1) cytoplasm (Calca)

Anatomy Link Frequency neurons 2 Grk1 (Mus musculus) Calca (Mus musculus)

Pain Link Frequency Relevance Heat Calcitonin gene-related peptide 4 100.00 Root ganglion neuron 1 99.48 qutenza 2 90.84

Disease Link Frequency Relevance Heat Ganglion Cysts 1 99.28 Alopecia 6 95.56 Targeted Disruption 1 76.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

RK, at concentrations higher than 1 microM, significantly increased CGRP release from dorsal root ganglion neurons (DRG) isolated from wild-type (WT) mice and this increase was completely reversed by capsazepine, an inhibitor of vanilloid receptor-1 activation.

RK Positive_regulation (increased) of Localization (release) of CGRP in neurons associated with ganglion cysts, root ganglion neuron and calcitonin gene-related peptide

1) Confidence 0.10 Published 2008 Journal Growth Horm. IGF Res. Section Abstract Doc Link 18321745 Disease Relevance 0.53 Pain Relevance 0.38

General Comments

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