INT150291

Context Info Confidence 0.16 First Reported 2008 Last Reported 2008 Negated 0 Speculated 1 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.98 Pain Relevance 0.55

extracellular space (Igf1) extracellular region (Igf1) kinase activity (Grk1)

Anatomy Link Frequency skin 4 Grk1 (Mus musculus) Igf1 (Mus musculus)

Pain Link Frequency Relevance Heat qutenza 4 98.88 Calcitonin gene-related peptide 8 88.72 Root ganglion neuron 2 86.72

Disease Link Frequency Relevance Heat Alopecia 12 100.00 Ganglion Cysts 2 86.32 Targeted Disruption 2 80.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These observations strongly suggest that RK might increase dermal IGF-I production through sensory neuron activation, thereby promoting hair growth and increasing skin elasticity.

RK Spec (might) Positive_regulation (increase) of Gene_expression (production) of IGF-I in skin associated with alopecia

1) Confidence 0.16 Published 2008 Journal Growth Horm. IGF Res. Section Abstract Doc Link 18321745 Disease Relevance 0.57 Pain Relevance 0.17

Thus, it is possible that RK activates sensory neurons, thereby increasing skin elasticity and promoting hair growth by increasing dermal IGF-I production.

RK Positive_regulation (increasing) of Gene_expression (production) of IGF-I in skin associated with alopecia

2) Confidence 0.15 Published 2008 Journal Growth Horm. IGF Res. Section Abstract Doc Link 18321745 Disease Relevance 0.41 Pain Relevance 0.39

General Comments

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