INT15039

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Context Info
Confidence 0.21
First Reported 1991
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NKX2-1) anatomical structure formation involved in morphogenesis (NKX2-1) nucleus (NKX2-1)
DNA binding (NKX2-1)
Anatomy Link Frequency
muscle 1
NKX2-1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 4 100.00 Very High Very High Very High
agonist 3 98.68 Very High Very High Very High
Central nervous system 1 95.12 Very High Very High Very High
qutenza 4 89.64 High High
Neuropeptide 2 87.28 High High
Potency 1 83.92 Quite High
Inflammation 3 83.04 Quite High
substance P 5 61.96 Quite High
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 4 50.00 Quite Low
Disease 1 5.00 Very Low Very Low Very Low
Asthma 1 5.00 Very Low Very Low Very Low
Neurogenic Inflammation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Maximal NK-2 receptor-mediated contraction was also significantly decreased in both longitudinal (71%, P < 0.001) and circular (51%, P < 0.01) muscle.
Negative_regulation (decreased) of NK-2 in muscle
1) Confidence 0.21 Published 2005 Journal J. Gastroenterol. Hepatol. Section Body Doc Link 15853981 Disease Relevance 0 Pain Relevance 0
Experiments with the putative NK-1 (L668, 169) or NK-2 (MEN 10,207, MEN 10,376, L659,877, and R396) selective antagonists against NK-1 and NK-2 selective agonists further supported this conclusion.
Negative_regulation (antagonists) of NK-2 associated with antagonist and agonist
2) Confidence 0.02 Published 1991 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 1713430 Disease Relevance 0 Pain Relevance 0.32
MDL 105,172A is a non-peptide, potent, equivalent antagonist of NK-1 and NK-2 receptors.
Negative_regulation (antagonist) of NK-2 associated with antagonist
3) Confidence 0.02 Published 1997 Journal J Auton Pharmacol Section Abstract Doc Link 9234081 Disease Relevance 0 Pain Relevance 0.39

General Comments

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