INT150465

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Context Info
Confidence 0.56
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 3.48
Pain Relevance 2.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2ry2) aging (P2ry2) plasma membrane (P2ry2)
embryo development (P2ry2) lysosome (P2ry2) signal transducer activity (P2ry2)
Anatomy Link Frequency
microglia 4
neurons 2
P2ry2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 22 99.68 Very High Very High Very High
trigeminal ganglion 12 98.56 Very High Very High Very High
Neuropathic pain 13 98.00 Very High Very High Very High
Lasting pain 3 94.24 High High
Sciatic nerve 2 92.92 High High
intrathecal 4 91.76 High High
dorsal root ganglion 53 90.56 High High
Pain 22 90.44 High High
antagonist 11 88.72 High High
cytokine 4 83.20 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 10 98.88 Very High Very High Very High
Ganglion Cysts 77 98.56 Very High Very High Very High
Neuropathic Pain 19 98.00 Very High Very High Very High
Pain 26 94.24 High High
Hypersensitivity 1 58.72 Quite High
Syndrome 1 53.04 Quite High
Nociception 19 28.12 Quite Low
Hyperalgesia 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Low Back Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Double labeling studies revealed that cells expressing increased P2Y(12) mRNA and protein after nerve injury were exclusively microglia.
Positive_regulation (increased) of Gene_expression (expressing) of P2Y in microglia associated with nervous system injury
1) Confidence 0.56 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18337420 Disease Relevance 0.85 Pain Relevance 0.89
A similar distribution of P2Y2 expression was observed in neurons of the rat TG [28].
Positive_regulation (distribution) of Gene_expression (expression) of P2Y2 in neurons associated with trigeminal ganglion
2) Confidence 0.34 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096565 Disease Relevance 1.64 Pain Relevance 0.71
Here, we show that the level of P2Y(12)R mRNA expression was markedly increased in the spinal cord ipsilateral to the nerve injury and that this expression was highly restricted to ionized binding calcium adapter molecule 1-positive microglia.
Positive_regulation (increased) of Gene_expression (expression) of P2Y in microglia associated with nervous system injury and spinal cord
3) Confidence 0.23 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18463248 Disease Relevance 0.99 Pain Relevance 0.73

General Comments

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