INT150537

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 2
Disease Relevance 0.38
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6) aging (IL6) extracellular region (IL6)
Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) plasma membrane (OPRM1)
Anatomy Link Frequency
monocytes 4
OPRM1 (Homo sapiens)
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 6 100.00 Very High Very High Very High
mu opioid receptor 2 100.00 Very High Very High Very High
cytokine 2 99.92 Very High Very High Very High
Inflammation 2 99.92 Very High Very High Very High
opioid receptor 2 82.24 Quite High
Disease Link Frequency Relevance Heat
Cancer 4 100.00 Very High Very High Very High
Necrosis 4 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: The mu opioid receptor mediates morphine-induced TNF and IL-6 inhibition in PGN-stimulated monocytes, but not in PBMCs.
mu opioid receptor Positive_regulation (mediates) of Negative_regulation (inhibition) of IL-6 in monocytes
1) Confidence 0.04 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18349186 Disease Relevance 0 Pain Relevance 0
The mu opioid receptor mediates morphine-induced tumor necrosis factor and interleukin-6 inhibition in toll-like receptor 2-stimulated monocytes.
mu opioid receptor Positive_regulation (mediates) of Negative_regulation (inhibition) of interleukin-6 in monocytes associated with necrosis, cancer, mu opioid receptor, cytokine and morphine
2) Confidence 0.04 Published 2008 Journal Anesth. Analg. Section Title Doc Link 18349186 Disease Relevance 0.38 Pain Relevance 0.48

General Comments

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