INT150548

Context Info Confidence 0.49 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 1.60 Pain Relevance 0.73

cytosol (MAP2K3) nucleoplasm (MAP2K3) signal transduction (MAP2K3)

Anatomy Link Frequency chondrocytes 2 MAP2K3 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 206 99.30 Inflammation 34 10.00 cytokine 16 5.00 Arthritis 16 5.00 metalloproteinase 12 5.00 rheumatoid arthritis 8 5.00 Pain 4 5.00 Inflammatory stimuli 2 5.00 Immobilon 2 5.00 imagery 2 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 208 99.30 Targeted Disruption 6 78.24 Apoptosis 5 67.40 INFLAMMATION 29 5.00 Arthritis 18 5.00 Disease 10 5.00 Rheumatoid Arthritis 8 5.00 Stress 3 5.00 Pain 2 5.00 Hypertrophy 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Sevoflurane exposure also induced phosphorylation of apoptosis signal-regulating kinase-1 (ASK1), MAP kinase kinases 3 and 6 (MKK3/MKK6), and ATF-2.

Positive_regulation (induced) of Phosphorylation (phosphorylation) of MKK3

1) Confidence 0.49 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18349187 Disease Relevance 0.07 Pain Relevance 0

-induced phosphorylation of both MKK3 and MKK6 in a dose dependent manner with the maximum inhibitory effect of PE being at 50 ?

Positive_regulation (induced) of Phosphorylation (phosphorylation) of MKK3

2) Confidence 0.47 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.91 Pain Relevance 0.42

Our results show that both MKK3 and MKK6 were constitutively phosphorylated in the primary human OA chondrocytes but the intensity of MKK3 phosphorylation was significantly enhanced (P < 0.05) after stimulation with IL-1?

Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of MKK3 in chondrocytes associated with osteoarthritis

3) Confidence 0.43 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.62 Pain Relevance 0.31

General Comments

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