INT150557

Context Info Confidence 0.32 First Reported 2008 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 8 Disease Relevance 0 Pain Relevance 0

nct (Mus musculus)

Pain Link Frequency Relevance Heat anesthesia 8 50.00

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

All of the values of NCT, CSI and the predicted effect site concentrations had a good linear correlation with OAA/S.

Regulation (values) of NCT

1) Confidence 0.32 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 20095351 Disease Relevance 0 Pain Relevance 0

CONCLUSION: A pharmacokinetic/pharmacodynamic model consisting of two sigmoid curves with an intervening plateau describes the effect of sevoflurane on BIS and NCT indices better than a model with a single sigmoid curve.

Regulation (effect) of NCT

2) Confidence 0.26 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18349189 Disease Relevance 0 Pain Relevance 0

To evaluate the relationship between concentrations and electroencephalographic indices, two different pharmacodynamic models were applied: a conventional model based on a single sigmoidal curve, and a novel model based on two sigmoidal curves for BIS and NCT values with and without burst suppression.

Regulation (values) of NCT

3) Confidence 0.15 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18349189 Disease Relevance 0 Pain Relevance 0

The predicted effect site concentrations of propofol at LOC was (2.15 +/- 0.27) mg/L while the values of NCT and CSI were 63.30 +/- 7.50 and 58.78 +/- 6.90 respectively.

Regulation (values) of NCT

4) Confidence 0.14 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 20095351 Disease Relevance 0 Pain Relevance 0

The predicted effect site concentrations of propofol at LVC was (1.56 +/- 0.13) mg/L while the values of NCT was 74.00 +/- 4.69 and CSI 69.82 +/- 5.47.

Regulation (values) of NCT

5) Confidence 0.14 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 20095351 Disease Relevance 0 Pain Relevance 0

The predicted effect site concentration of propofol, the values of CSI and NCT were recorded and the sedation level was examined by the modified OAA/S every 20 s.

Regulation (values) of NCT

6) Confidence 0.14 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 20095351 Disease Relevance 0 Pain Relevance 0

The values of NCT were higher significantly than that of CSI in different degree of LOC (P < 0.01).

Regulation (values) of NCT

7) Confidence 0.14 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 20095351 Disease Relevance 0 Pain Relevance 0

The predicted effect site concentrations of propofol and the values of NCT and CSI at LVC and LOC of the patients were recorded.

Regulation (values) of NCT

8) Confidence 0.14 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 20095351 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.