INT150851

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2011
Negated 1
Speculated 2
Reported most in Body
Documents 45
Total Number 47
Disease Relevance 20.83
Pain Relevance 11.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl1) extracellular region (Cxcl1)
Anatomy Link Frequency
liver 5
lung 5
neutrophil 3
plasma 2
retinas 2
Cxcl1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 646 100.00 Very High Very High Very High
chemokine 594 100.00 Very High Very High Very High
agonist 56 99.44 Very High Very High Very High
Inflammation 999 98.74 Very High Very High Very High
Inflammatory response 207 97.72 Very High Very High Very High
Inflammatory mediators 104 96.76 Very High Very High Very High
cva 19 93.68 High High
imagery 11 90.52 High High
tolerance 47 88.60 High High
antagonist 17 86.80 High High
Disease Link Frequency Relevance Heat
Injury 653 98.92 Very High Very High Very High
Pneumonia 105 98.74 Very High Very High Very High
Chlamydia Infection 120 98.32 Very High Very High Very High
INFLAMMATION 1255 98.08 Very High Very High Very High
Asthma 129 97.98 Very High Very High Very High
Adhesions 108 97.84 Very High Very High Very High
Apoptosis 76 97.76 Very High Very High Very High
Lung Injury 188 96.88 Very High Very High Very High
Disease Progression 3 96.60 Very High Very High Very High
Mycobacterial Infection 145 95.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Levels of CXCR2 chemokine ligands at earlier timepoints showed only a small increase (two-fold) in the induction of KC/CXCL1 and MIP-2/CXCL2/3 as early as 4 h following dsRNA-exposure (data not shown), but the maximal increase (>ten-fold for KC/CXCL1 and >four-fold for MIP-2/CXCL2/3) occurred at 72 h following dsRNA-exposure.


Positive_regulation (induction) of KC/CXCL1 associated with chemokine
1) Confidence 0.57 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.13 Pain Relevance 0.16
cells, followed by an increase in transcripts of chemokine genes (cxcl1, cxcl5, and ccl7) and of other genes typical of the myelo-monocytic lineages during disease progression [111].
Positive_regulation (increase) of cxcl1 associated with chemokine and disease progression
2) Confidence 0.57 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 1.06 Pain Relevance 0.25
It has been previously demonstrated that CXCL1 is increased in the kidney in ischemic AKI [33, 34, 63].
Positive_regulation (increased) of CXCL1 in kidney associated with injury
3) Confidence 0.57 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 1.08 Pain Relevance 0.20
Inhibition of macrophage infiltration in the kidney using liposomal encapsulated clodronate prevented the increase in CXCL1 in the kidney suggesting that macrophages are the main source of CXCL1 in ischemic AKI.
Positive_regulation (increase) of CXCL1 in macrophages associated with injury
4) Confidence 0.57 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 1.26 Pain Relevance 0.12
The supernatants from epithelial cells also accumulated IL-6, CXCL1, and CCL20, in a concentration dependent manner for each LPS examined (Fig. 5E–G; ANOVA, P<0.05), although the epithelial cells secreted little PGE (Fig. 5H).
Positive_regulation (accumulated) of CXCL1 in epithelial cells
5) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943929 Disease Relevance 0.30 Pain Relevance 0.18
The supernatants from stromal cells accumulated IL-6, CXCL1, CCL20, and PGE in a concentration dependent manner for each LPS examined (Fig. 5A–D; ANOVA, P<0.05).
Positive_regulation (accumulated) of CXCL1 in stromal cells
6) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943929 Disease Relevance 0.33 Pain Relevance 0.20
The increase in TNF-alpha levels preceded the increase in IL-1beta and KC/CXCL1.
Positive_regulation (increase) of CXCL1
7) Confidence 0.45 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18372199 Disease Relevance 0.28 Pain Relevance 0.24
The question why CD4+/CD25+ T cells are reduced in asthmatic patients has not been answered yet; however, it has been observed that these cells reveal a reduced response to the chemokines CCL1 and CXCL1 suggesting an impaired recruitment to the lung [137, 138].
Positive_regulation (response) of CXCL1 in T cells associated with asthma and chemokine
8) Confidence 0.42 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 1.09 Pain Relevance 0.12
The I/R procedure incremented (from doubling to nearly trebling) tissue levels of MCP-1 and KC (Fig. 3).
Positive_regulation (incremented) of KC
9) Confidence 0.42 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.10 Pain Relevance 0.14
Levels of CXCR2 chemokine ligands at earlier timepoints showed only a small increase (two-fold) in the induction of KC/CXCL1 and MIP-2/CXCL2/3 as early as 4 h following dsRNA-exposure (data not shown), but the maximal increase (>ten-fold for KC/CXCL1 and >four-fold for MIP-2/CXCL2/3) occurred at 72 h following dsRNA-exposure.


Positive_regulation (fold) of KC/CXCL1 associated with chemokine
10) Confidence 0.41 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.13 Pain Relevance 0.16
DsRNA treatment resulted in significant increases in lung KC/CXCL1 mRNA levels as well as in protein levels from whole lung homogenates and BAL when compared to controls (Fig. 5A, C, and 5E) at 72 h following dsRNA treatment.
Positive_regulation (increases) of KC/CXCL1 in lung
11) Confidence 0.39 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.19 Pain Relevance 0.13
The finding of increased levels of KC/CXCL1 and MIP-2/CXCL2/3 associated with dsRNA-induced neutrophil sequestration and lung injury led us to evaluate the expression of CXCR2 mRNA in the lungs of these animals.
Positive_regulation (increased) of KC/CXCL1 in lung associated with lung injury
12) Confidence 0.39 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.27 Pain Relevance 0.15
Quantification of their contents in the mesenteric tissue of MC3R-null mice revealed 1) a pronounced response after the I/R procedure as assessed at 90 min postreperfusion with remarkable increases in both chemokines; and 2) a significant increment in the local levels of KC (Fig. 3B) when compared with WT mice, whereas no significant changes could be measured with respect to MCP-1 (Fig. 3A).
Positive_regulation (increment) of KC associated with chemokine
13) Confidence 0.37 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.08 Pain Relevance 0.16
Although LPS stimulation seemed to increase the mRNA for IL-6, CXCL-1 and CSF-2; the mRNA levels for these 3 genes were not significantly different from the untreated cells (Table 1).


Positive_regulation (increase) of CXCL-1
14) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2995738 Disease Relevance 0.07 Pain Relevance 0.23
Subsequent experiments used ultrapure LPS from E. coli and focused on the accumulation of IL-6, CXCL1, CCL20, and PGE.
Positive_regulation (accumulation) of CXCL1
15) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943929 Disease Relevance 0.26 Pain Relevance 0.11
Epithelial cell supernatants also accumulated more IL-6, CXCL1 and CCL20 in response to LPS over time (ANOVA, P<0.001) and in a treatment dependent manner (ANOVA, P<0.001) for each mediator.
Positive_regulation (accumulated) of CXCL1 in Epithelial cell
16) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943929 Disease Relevance 0.24 Pain Relevance 0.12
Supernatants of the stromal cells treated with LPS accumulated IL-6, CXCL1, CCL20 and PGE over time (ANOVA, P<0.001) and in a treatment dependent manner (ANOVA, P<0.001) for each inflammatory mediator.
Positive_regulation (accumulated) of CXCL1 in stromal cells associated with inflammation
17) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943929 Disease Relevance 0.25 Pain Relevance 0.13
This enhanced response is associated with increases in the level of neutrophil-attracting chemokines KC and MIP-2, known to play a role in adhesiogenesis.
Positive_regulation (increases) of KC in neutrophil associated with chemokine
18) Confidence 0.34 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18453619 Disease Relevance 0.97 Pain Relevance 0.12
induced the following cytokines (listed in order of induction levels): KC, IL-1?
Positive_regulation (induced) of KC associated with chemokine and cytokine
19) Confidence 0.34 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.39 Pain Relevance 0.81
GRO-1 and IL-6 protein and mRNA levels were significantly elevated in the venous occlusion group compared to sham.
Positive_regulation (elevated) of GRO-1
20) Confidence 0.30 Published 2009 Journal Ann Vasc Surg Section Abstract Doc Link 18640815 Disease Relevance 0.87 Pain Relevance 0.42

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