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Context Info
Confidence 0.23
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.68
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SERPINA5) extracellular space (SERPINA5) extracellular region (SERPINA5)
protein complex (SERPINA5)
Anatomy Link Frequency
brain 2
Plasma 1
arm 1
SERPINA5 (Homo sapiens)
Pain Link Frequency Relevance Heat
intrathecal 6 94.48 High High
dexamethasone 3 83.00 Quite High
imagery 13 81.76 Quite High
Angina 11 75.00 Quite High
Inflammatory response 2 75.00 Quite High
cva 106 65.68 Quite High
Inflammatory marker 1 58.04 Quite High
depression 20 43.24 Quite Low
Inflammation 3 34.08 Quite Low
ischemia 35 32.32 Quite Low
Disease Link Frequency Relevance Heat
Recurrence 9 99.82 Very High Very High Very High
Coronary Artery Disease 36 99.44 Very High Very High Very High
Toxicity 31 98.52 Very High Very High Very High
Cancer 41 98.32 Very High Very High Very High
Myocardial Infarction 80 98.12 Very High Very High Very High
Metastasis 64 97.98 Very High Very High Very High
Acute Coronary Syndrome 35 95.72 Very High Very High Very High
Cognitive Disorder 51 93.44 High High
Fatigue 9 91.32 High High
Alopecia 4 90.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For individual patients demonstrating brain metastases following PCI, it can be difficult to determine the relative contribution of the recurrence and the PCI when neurocognitive decline is identified [52].
Negative_regulation (decline) of PCI in brain associated with recurrence and metastasis
1) Confidence 0.23 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2910483 Disease Relevance 1.20 Pain Relevance 0
Approaches to preventing or reducing this toxicity include the use of stereotactic radiosurgery (SRS) instead of WBRT; dose reduction for PCI; exclusion of the limbic circuit, hippocampal formation, and/or neural stem cell regions of the brain during radiotherapy; avoidance of intrathecal and/or systemic chemotherapy during radiotherapy; the use of high-dose, systemic chemotherapy in lieu of WBRT.
Negative_regulation (reduction) of PCI in brain associated with toxicity and intrathecal
2) Confidence 0.23 Published 2010 Journal Journal of Oncology Section Abstract Doc Link PMC2910483 Disease Relevance 0.43 Pain Relevance 0.09
Limitations, including the previously described detection bias for MI [55] and unbalancing of adjunctive therapies following randomization (less platelet IIb/IIIa blockade during cross-over PCI in the conservative arm than in the invasive arm and more oral antiplatelet therapy in the invasive arm) cloud any interpretation of superiority.
Negative_regulation (blockade) of PCI in arm associated with myocardial infarction
3) Confidence 0.20 Published 2006 Journal BMC Med Section Body Doc Link PMC1617111 Disease Relevance 0.62 Pain Relevance 0.03
Plasma hsCRP, Hu TNF-alpha, and IL-6 levels were determined before intervention and at 24 h, 48 h, and 1 week after PCI.
Negative_regulation (week) of PCI in Plasma
4) Confidence 0.14 Published 2008 Journal Heart Vessels Section Abstract Doc Link 18389330 Disease Relevance 0.95 Pain Relevance 0.44
Other noteworthy reviews concerning effectiveness of PCI and CABG for CAD include one by the Agency for Healthcare Research and Quality247 and a recent narrative.248


Negative_regulation (effectiveness) of PCI associated with coronary artery disease
5) Confidence 0.03 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941787 Disease Relevance 0.48 Pain Relevance 0.08

General Comments

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