INT151168

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Context Info
Confidence 0.78
First Reported 2003
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 60
Total Number 61
Disease Relevance 35.63
Pain Relevance 10.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Pten) mitochondrion (Pten) plasma membrane (Pten)
nucleus (Pten) intracellular (Pten) enzyme binding (Pten)
Anatomy Link Frequency
DA neurons 6
muscle 4
skeletal muscle 3
brain 2
striatum 2
Pten (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 4 100.00 Very High Very High Very High
Dopamine 2185 99.84 Very High Very High Very High
rheumatoid arthritis 274 99.80 Very High Very High Very High
metalloproteinase 128 99.30 Very High Very High Very High
Substantia nigra 152 98.68 Very High Very High Very High
agonist 95 98.64 Very High Very High Very High
Catecholamine 19 98.60 Very High Very High Very High
Nucleus accumbens 19 97.32 Very High Very High Very High
midbrain 285 97.24 Very High Very High Very High
Ventral tegmentum 152 97.10 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 1167 100.00 Very High Very High Very High
Apoptosis 562 100.00 Very High Very High Very High
Targeted Disruption 404 100.00 Very High Very High Very High
Disease 353 100.00 Very High Very High Very High
Rheumatoid Arthritis 278 99.80 Very High Very High Very High
Autism 10 99.78 Very High Very High Very High
Adenocarcinoma 245 99.68 Very High Very High Very High
Prostate Cancer 16 99.64 Very High Very High Very High
Hepatocellular Cancer 113 99.60 Very High Very High Very High
Hypertrophy 252 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Suppressing PTEN expression protects DA neurons against exposure to a neurotoxin
Gene_expression (expression) of PTEN in DA neurons associated with dopamine
1) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.15 Pain Relevance 0.34
Mice lacking PTEN expression in DA cells showed an increase in catecholamine content in both the midbrain containing the DA cell bodies (fig. 6D) and in the terminal region in the dorsal striatum (fig. 6B).
Gene_expression (expression) of PTEN in striatum associated with dopamine, catecholamine and midbrain
2) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 1.01
Even though we looked at 5 mouse strains, it is still possible that the disparity in PTEN expression is the result of differences in the background strain of the transgenic line.
Gene_expression (expression) of PTEN associated with targeted disruption and sprains and strains
3) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.69 Pain Relevance 0
It is interesting to note that even though skeletal muscle is highly insulin sensitive and has a low incidence of transformation, PTEN is expressed at a substantially lower level in skeletal muscle than any other tissue analysed.
Gene_expression (expressed) of PTEN in skeletal muscle
4) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.17 Pain Relevance 0
PTEN is widely distributed in the brain and is preferentially expressed in neurons, where it localizes to both the nucleus and cytoplasm [4]–[7].
Gene_expression (expressed) of PTEN in neurons
5) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 1.19 Pain Relevance 0
The relationship between PTEN and Parkinson’s disease has been emphasized in several studies often in reference to mitochondrial function.
Gene_expression (disease) of PTEN associated with disease
6) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.22 Pain Relevance 0.30
Interestingly, PTEN ablation did not generate changes in TH optical density in the striatum or nucleus accumbens, suggesting an equal distribution of dopaminergic terminals between Pten KO and control animals.
Gene_expression (ablation) of PTEN in nucleus accumbens associated with nucleus accumbens
7) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.29 Pain Relevance 0.50
The effects of PTEN deletion in DA neurons, as well as postsynaptic regions will be discussed in detail below.
Gene_expression (deletion) of PTEN in DA neurons associated with dopamine
8) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.29 Pain Relevance 0.46
In a previous report we first detected DAT-Cre mediated beta galactosidase expression in a conditional Rosa26LacZ reporter mice at embryonic day 17 [15], suggesting excision of Pten exon5 at around this developmental point.
Gene_expression (excision) of Pten
9) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.27 Pain Relevance 0.38
Disruption of PTEN activity in DA neurons during postmitotic developmental growth
Gene_expression (activity) of PTEN in DA neurons associated with dopamine
10) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.43 Pain Relevance 0.45
PTEN ablation in DA neurons (n?
Gene_expression (ablation) of PTEN in DA neurons associated with dopamine
11) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.16 Pain Relevance 0.29
The expression level of clonidine-induced phosphorylated PTEN (phosphatase and tensin homolog deleted on chromosome ten) was significantly increased in diabetic aortas, but chronic simvastatin did not affect it.
Gene_expression (expression) of PTEN in aortas associated with diabetes mellitus and clonidine
12) Confidence 0.62 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18391484 Disease Relevance 0.92 Pain Relevance 0.35
In the SOL muscle, there was no effect of PTEN ablation on insulin stimulated PKB Thr308 phosphorylation (Figure S2).
Gene_expression (ablation) of PTEN in muscle
13) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.23 Pain Relevance 0
The MCK-Cre and PTEN flox/flox mice were mated and the subsequent offspring were then used as breeders to generate MCK-Cre controls termed PTEN+/+ (PTEN+/+ MCK-Cre+/?)
Gene_expression (/) of PTEN
14) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.07 Pain Relevance 0.04
The MCK-Cre and PTEN flox/flox mice were mated and the subsequent offspring were then used as breeders to generate MCK-Cre controls termed PTEN+/+ (PTEN+/+ MCK-Cre+/?)
Gene_expression (mated) of PTEN
15) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.13 Pain Relevance 0.04
The MCK-Cre and PTEN flox/flox mice were mated and the subsequent offspring were then used as breeders to generate MCK-Cre controls termed PTEN+/+ (PTEN+/+ MCK-Cre+/?)
Gene_expression (/) of PTEN
16) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.07 Pain Relevance 0.04
Therefore, while the increased activation of PKB in the overloaded PLN muscle of the PTEN?
Gene_expression (muscle) of PTEN in muscle
17) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.22 Pain Relevance 0
PCR products were then subjected to electrophoresis on a 2% agarose gel and genotype was established by the presence of a 500 bp band from the MCK-Cre reaction and either a 200 bp product for PTEN?
Gene_expression (product) of PTEN in band
18) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0 Pain Relevance 0
To confirm if Pten deletion was specific to DAT expressing regions, primers specific to the recombination (delta5) were developed.
Gene_expression (deletion) of Pten
19) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.15 Pain Relevance 0.25
We found that Pten deletion protects DA neurons during this partial 6OHDA lesion and prevents fiber loss in the lesioned striatum when compared to control animals.
Gene_expression (deletion) of Pten in striatum associated with dopamine
20) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 0.58

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