INT151217

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.41
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SIGMAR1) nuclear envelope (SIGMAR1) lipid particle (SIGMAR1)
endoplasmic reticulum (SIGMAR1) plasma membrane (SIGMAR1) nucleus (SIGMAR1)
SIGMAR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 11 99.72 Very High Very High Very High
Immobilon 7 97.72 Very High Very High Very High
opioid receptor 5 86.08 High High
cytokine 1 60.28 Quite High
Enkephalin 1 39.12 Quite Low
Pain 3 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 3 76.96 Quite High
Fracture Healing 32 75.48 Quite High
Osteoporosis 7 66.40 Quite High
Injury 18 5.00 Very Low Very Low Very Low
Tibial Fractures 12 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 6 5.00 Very Low Very Low Very Low
Infection 6 5.00 Very Low Very Low Very Low
Pressure Volume 2 Under Development 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Osteogenic Sarcomas 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After binding BMP-2, the type II receptor kinase phosphorylates the type I receptor, generating an intracellular response.
Phosphorylation (phosphorylates) of type I receptor
1) Confidence 0.04 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721393 Disease Relevance 0.26 Pain Relevance 0.03
Third, correlation between functional experiments and phosphorylation of the hDOP-R after agonist activation was assessed by western-blot using the specific anti-phospho-DOP-R Ser(363) antibody.
Phosphorylation (hosphorylation ) of hDOP-R associated with agonist
2) Confidence 0.00 Published 2008 Journal Cell. Signal. Section Abstract Doc Link 18395423 Disease Relevance 0.15 Pain Relevance 0.69

General Comments

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