INT151511

Context Info Confidence 0.02 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.75 Pain Relevance 0.47

extracellular region (Cyr61) cell adhesion (Cyr61) proteinaceous extracellular matrix (Cyr61) extracellular matrix organization (Cyr61)

Anatomy Link Frequency mast cells 1 Cyr61 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammation 11 100.00 metalloproteinase 1 98.68 Analgesic 1 62.88 Pain 1 55.56

Disease Link Frequency Relevance Heat INFLAMMATION 8 100.00 Granuloma 2 85.16 Pain 1 55.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The anti-inflammatory effect was due to the modulation of mast cells degranulation, as shown by histological analysis and by the inhibition of the release of several pro-inflammatory and pro-angiogenic enzymes (e.g. iNOS, chymase and metalloproteinase MMP-9), and mediators (e.g. nitric oxide and TNF-alpha).

Localization (release) of pro-angiogenic in mast cells associated with inflammation and metalloproteinase

1) Confidence 0.02 Published 2009 Journal J. Cell. Mol. Med. Section Abstract Doc Link 18429935 Disease Relevance 0.75 Pain Relevance 0.47

General Comments

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