INT151742

Context Info Confidence 0.41 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 0.89 Pain Relevance 0.17

cytosol (PLEC) plasma membrane (PLEC) cytoplasm (PLEC)

Anatomy Link Frequency brain 2 PLEC (Homo sapiens)

Pain Link Frequency Relevance Heat Potency 1 94.68 Snapping jaw 1 69.88 cva 16 56.40 ischemia 2 19.28 deep brain stimulation 12 5.00 Anterior cingulate 12 5.00 cerebral cortex 6 5.00 insula 6 5.00 Pain 6 5.00 hyperexcitability 2 5.00

Disease Link Frequency Relevance Heat Cognitive Disorder 16 98.32 Hallucination 12 94.68 Pressure And Volume Under Development 1 88.40 Cerebral Edema 1 82.88 Epilepsy 14 79.12 Temporomandibular Joint Syndrome 1 69.88 Persistent Vegetative State 1 68.20 Convulsion 12 67.84 Death 2 67.48 Intracranial Hypertension 11 56.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The effect of EBS needs to be studied during behavioral or cognitive tasks that are specifically tailored to examine the functional role of a brain region.

Positive_regulation (effect) of EBS in brain associated with cognitive disorder

1) Confidence 0.41 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC2889679 Disease Relevance 0.10 Pain Relevance 0

Moreover, a comprehensive map of old and new EBS studies could provide useful data about the possible involvement of a brain region in the genesis of a particular set of illusions, hallucinations, delusional ideations and automatic behavior experienced by patients with psychiatric disorders.

Positive_regulation (map) of EBS in brain associated with hallucination

2) Confidence 0.41 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC2889679 Disease Relevance 0.31 Pain Relevance 0

However, the number of patients in each group that reached EBS was not reported; therefore, it is unclear whether bioequivalent doses were actually achieved between groups.

Positive_regulation (reached) of EBS

3) Confidence 0.39 Published 2008 Journal Crit Care Section Body Doc Link PMC2592754 Disease Relevance 0.42 Pain Relevance 0.10

TGF-beta 3 with BMP-4 yielded EBs positive for collagens I, II, and VI, with up to 6.7- and 4.8-fold increases in GAG and collagen, respectively.

Positive_regulation (increases) of EBs

4) Confidence 0.04 Published 2009 Journal Stem Cells Dev. Section Abstract Doc Link 18454697 Disease Relevance 0.07 Pain Relevance 0.07

General Comments

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