INT151809

Context Info Confidence 0.32 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.74

nucleoplasm (JUN) nuclear chromosome (JUN) aging (JUN) Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) DNA binding (JUN)

Anatomy Link Frequency NFAT 2 JUN (Homo sapiens) OPRM1 (Homo sapiens)

Pain Link Frequency Relevance Heat opioid receptor 7 100.00 Opioid 4 84.96 Morphine 3 84.44 Kappa opioid receptor 1 81.68 opiate 1 76.80 mu opioid receptor 2 75.00 antagonist 1 50.64 Enkephalin 1 25.00

|}

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Transcriptional induction of the mu-opioid receptor gene was mediated by activator protein-1 (AP-1), nuclear factor-kappaB, and nuclear factor of activated T cells (NFAT).

AP-1 Positive_regulation (mediated) of Positive_regulation (induction) of mu-opioid receptor gene in NFAT associated with opioid receptor

1) Confidence 0.32 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18463202 Disease Relevance 0 Pain Relevance 0.74

General Comments

This test has worked.