INT151816

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Context Info
Confidence 0.02
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 3.10
Pain Relevance 2.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry2) mitochondrion (P2ry2) plasma membrane (P2ry2)
lysosome (P2ry2) signal transducer activity (P2ry2)
Anatomy Link Frequency
nerve 2
fibroblasts 1
P2ry2 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropathic pain 12 98.84 Very High Very High Very High
Brush evoked pain 6 98.80 Very High Very High Very High
Stimulus evoked pain 2 96.68 Very High Very High Very High
antagonist 3 93.40 High High
intrathecal 4 92.08 High High
Spinal cord 4 85.52 High High
Peripheral nerve injury 2 75.00 Quite High
Lasting pain 2 67.76 Quite High
agonist 3 49.96 Quite Low
Hyperesthesia 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Syndrome 2 99.20 Very High Very High Very High
Neuropathic Pain 18 98.84 Very High Very High Very High
Diabetes Mellitus 1 98.40 Very High Very High Very High
Nervous System Injury 10 97.84 Very High Very High Very High
Hypersensitivity 2 96.68 Very High Very High Very High
Pain 5 96.00 Very High Very High Very High
Hyperglycemia 1 86.48 High High
Impaired Glucose Tolerance 10 52.00 Quite High
Insulin Resistance 4 50.32 Quite High
Body Weight 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, mice lacking P2ry(12) (P2ry(12)(-/-)) displayed impaired tactile allodynia after nerve injury without any change in basal mechanical sensitivity.
Negative_regulation (lacking) of P2ry in nerve associated with brush evoked pain and nervous system injury
1) Confidence 0.02 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18463248 Disease Relevance 1.41 Pain Relevance 1.12
Furthermore, mice lacking P2ry(12) (P2ry(12)(-/-)) displayed impaired tactile allodynia after nerve injury without any change in basal mechanical sensitivity.
Negative_regulation (lacking) of P2ry in nerve associated with brush evoked pain and nervous system injury
2) Confidence 0.02 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18463248 Disease Relevance 1.40 Pain Relevance 1.12
In fibroblasts from type 2 diabetic patients, this P2-mediated glucose transport was defective due to constitutive P2Y desensitization in these cells, while co-incubation with the nucleotide degrading enzyme apyrase restored ATP-stimulated glucose uptake.
Negative_regulation (desensitization) of P2Y in fibroblasts associated with diabetes mellitus
3) Confidence 0.01 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.29 Pain Relevance 0

General Comments

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