INT15204

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Context Info
Confidence 0.32
First Reported 1991
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0.43
Pain Relevance 2.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Sub1) nucleus (Sub1) DNA binding (Sub1)
Anatomy Link Frequency
corpus 1
anterior 1
SUB 1
ENT 1
Sub1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 4 100.00 Very High Very High Very High
antagonist 3 99.68 Very High Very High Very High
substance P 6 99.42 Very High Very High Very High
Dopamine 8 98.76 Very High Very High Very High
tetrodotoxin 16 98.64 Very High Very High Very High
TRP channel 1 98.20 Very High Very High Very High
qutenza 9 96.76 Very High Very High Very High
medulla 1 91.60 High High
agonist 3 90.92 High High
Spinal cord 1 87.36 High High
Disease Link Frequency Relevance Heat
Ulcers 1 90.68 High High
Disease 2 86.48 High High
Schizophrenia 7 85.92 High High
Nociception 1 85.24 High High
Nerve Degeneration 1 50.00 Quite Low
Pain 1 5.00 Very Low Very Low Very Low
Psychosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, after reversible inactivation of the SUB during the pre-exposure session, TTX-pre-exposed conditioned animals displayed aversive behaviour in the test session, and anterior striatal DA variations in these animals differed significantly from those obtained in pre-exposed rats injected locally with PBS.
Negative_regulation (inactivation) of SUB in anterior associated with tetrodotoxin
1) Confidence 0.32 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16262643 Disease Relevance 0 Pain Relevance 0.33
The I(Sub-P) was reversed at approximately -20 mV, blocked by several TRP channel blockers, enhanced by OAG and negatively regulated by PKC.
Negative_regulation (reversed) of Sub-P associated with trp channel
2) Confidence 0.17 Published 2009 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 19463951 Disease Relevance 0.09 Pain Relevance 0.33
Treatment with the neurokinin antagonist [D-Arg1, D-Trp7,9 Leu11]-Substance P (spantide) dose-dependently inhibits Sub.
Negative_regulation (inhibits) of Sub associated with antagonist and substance p
3) Confidence 0.16 Published 1991 Journal J Pharmacol Methods Section Abstract Doc Link 1717793 Disease Relevance 0 Pain Relevance 0.34
This study examines the consequences of a neonatal transitory blockade of the left ENT or left SUB for latent inhibition-related dopamine responses in the anterior part of the dorsal striatum using in-vivo voltammetry in freely moving adult rats.
Spec (examines) Negative_regulation (blockade) of SUB in SUB associated with dopamine
4) Confidence 0.08 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19453628 Disease Relevance 0.26 Pain Relevance 0.32
These data suggest that neonatal functional inactivation of the SUB disrupts latent inhibition-related striatal dopamine responses in adult animals more than that of the ENT.
Negative_regulation (inactivation) of SUB in ENT associated with dopamine
5) Confidence 0.08 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19453628 Disease Relevance 0 Pain Relevance 0.67
From the above results, it was suggested that capsaicin-treatment decreased the gastroprotective ability in the antrum to a greater extent than in the corpus and this may be caused by the decrease of GMBF through the decrease of CGRP- and Sub P-immunoreactive substances.
Negative_regulation (decrease) of Sub P in corpus associated with qutenza and calcitonin gene-related peptide
6) Confidence 0.08 Published 1993 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 7690431 Disease Relevance 0.09 Pain Relevance 0.75

General Comments

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