INT15209

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Context Info
Confidence 0.51
First Reported 1983
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 1.64
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) nucleus (Th)
response to stress (Th) cytoplasm (Th)
Anatomy Link Frequency
SNc 3
striatum 1
Th (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Catecholamine 5 100.00 Very High Very High Very High
tetrodotoxin 1 99.98 Very High Very High Very High
halothane 4 99.84 Very High Very High Very High
anesthesia 5 99.44 Very High Very High Very High
sodium channel 1 99.44 Very High Very High Very High
Ventral tegmentum 30 96.40 Very High Very High Very High
noradrenaline 8 89.84 High High
Dopamine 42 89.68 High High
fluoxetine 70 88.56 High High
sSRI 38 88.08 High High
Disease Link Frequency Relevance Heat
Nerve Degeneration 1 89.44 High High
Ganglion Cysts 4 83.96 Quite High
Death 4 82.40 Quite High
Drug Induced Neurotoxicity 4 82.24 Quite High
Paralysis 2 69.88 Quite High
Parkinson's Disease 95 66.16 Quite High
Pressure And Volume Under Development 2 64.64 Quite High
Cognitive Disorder 16 64.20 Quite High
Anxiety Disorder 12 63.60 Quite High
Depression 21 63.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sodium channel blockade with tetrodotoxin prevented the effects of veratridine on SS and TH mRNAs.
Negative_regulation (prevented) of Regulation (effects) of TH associated with tetrodotoxin and sodium channel
1) Confidence 0.51 Published 1989 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2564623 Disease Relevance 0.33 Pain Relevance 0.15
The latter significantly decreased also the stimulant effect of i.v. haloperidol on striatal TH activity.
Negative_regulation (decreased) of Regulation (effect) of TH
2) Confidence 0.38 Published 1983 Journal Brain Res. Section Abstract Doc Link 6133578 Disease Relevance 0.07 Pain Relevance 0.22
Moreover, the results indicate that the mechanism responsible for firing and TH stimulation is inhibited by halothane anesthesia.
Negative_regulation (inhibited) of Regulation (responsible) of TH associated with anesthesia and halothane
3) Confidence 0.37 Published 1983 Journal Brain Res. Section Abstract Doc Link 6133578 Disease Relevance 0.07 Pain Relevance 0.22
A single unilateral injection of 6-OHDA into the rat SNc resulted in an almost complete loss of tyrosine hydroxylase (TH) immunoreactivity in the striatum and SNc, as well as in reductions of TH-positive cells and fibers in the ventral tegmental area (VTA).
Negative_regulation (loss) of Regulation (immunoreactivity) of tyrosine hydroxylase in SNc associated with ventral tegmentum
4) Confidence 0.31 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2822849 Disease Relevance 0.41 Pain Relevance 0.59
Denervation had no effect on TH mRNA levels until 8 days after surgery, and after 11 days both TH mRNA and catecholamine levels had decreased by 35-45%.
Negative_regulation (decreased) of Neg (no) Regulation (effect) of TH mRNA associated with catecholamine
5) Confidence 0.28 Published 1991 Journal Mol. Pharmacol. Section Abstract Doc Link 1717819 Disease Relevance 0 Pain Relevance 0.25
The quantitative analysis indicated that alpha-synuclein expression in the SNc was up-regulated by 156.1% in 12-µg group as compared to 3-µg group (Figure 5E, I and Figure 4L), while the TH immunoreactivities in the lesioned SNc were decreased by 38.6% and 77.3% as compared to the contralateral SNc (Figure 5B, F, J and Figure 4L).


Negative_regulation (decreased) of Regulation (immunoreactivities) of TH
6) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2774159 Disease Relevance 0.36 Pain Relevance 0.16
A single unilateral injection of 6-OHDA into the rat SNc resulted in an almost complete loss of tyrosine hydroxylase (TH) immunoreactivity in the striatum and SNc, as well as in reductions of TH-positive cells and fibers in the ventral tegmental area (VTA).
Negative_regulation (loss) of in striatum Regulation (immunoreactivity) of tyrosine hydroxylase in SNc associated with ventral tegmentum
7) Confidence 0.11 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2822849 Disease Relevance 0.41 Pain Relevance 0.59

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