INT15210

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Context Info
Confidence 0.59
First Reported 1989
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 0.47
Pain Relevance 2.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) nucleus (Th)
response to stress (Th) cytoplasm (Th)
Anatomy Link Frequency
neuronal 2
substantia nigra 2
adrenal gland 2
dopaminergic neurons 2
Th (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 10 100.00 Very High Very High Very High
Endogenous opioid 2 99.62 Very High Very High Very High
Substantia nigra 4 99.36 Very High Very High Very High
Catecholamine 14 99.18 Very High Very High Very High
Dopamine 4 98.80 Very High Very High Very High
Ventral tegmentum 2 94.64 High High
Nucleus accumbens 1 93.36 High High
medulla 5 90.80 High High
Enkephalin 15 88.00 High High
antagonist 1 87.08 High High
Disease Link Frequency Relevance Heat
Stress 1 98.08 Very High Very High Very High
Ganglion Cysts 4 94.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These differential effects suggest suppression of endogenous TH gene transcription, targeted degradation of TH mRNA or both.
Negative_regulation (suppression) of Transcription (transcription) of TH gene
1) Confidence 0.59 Published 2007 Journal Brain Res. Section Abstract Doc Link 17174279 Disease Relevance 0 Pain Relevance 0.19
By contrast, denervation decreased levels of tyrosine hydroxylase (TH) mRNA.
Negative_regulation (decreased) of Transcription (levels) of tyrosine hydroxylase
2) Confidence 0.43 Published 1989 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2564623 Disease Relevance 0.37 Pain Relevance 0.13
Dietary butyrate may have an extended role in the control of catecholamine and endogenous opioid production at the level of TH and ppEnk gene transcription neuronal plasticity, cardiovascular functions, stress adaptation and behavior.
Negative_regulation (level) of Transcription (transcription) of TH in neuronal associated with stress, catecholamine and endogenous opioid
3) Confidence 0.42 Published 2005 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 16165221 Disease Relevance 0.10 Pain Relevance 0.18
We assessed mRNA levels of tyrosine hydroxylase (TH), a major regulatory enzyme in the dopamine synthesis and levels of dopamine and its metabolites after chronic ethanol administration with and without concomitant naltrexone.
Negative_regulation (assessed) of Transcription (levels) of TH associated with dopamine
4) Confidence 0.42 Published 2005 Journal Alcohol Alcohol. Section Abstract Doc Link 15897221 Disease Relevance 0 Pain Relevance 0.42
Tyrosine hydroxylase (TH) mRNA levels were increased nearly 7-fold (686 +/- 71%) 24 hr after the first reserpine dose and declined thereafter.
Negative_regulation (declined) of Transcription (levels) of TH
5) Confidence 0.41 Published 1991 Journal Mol. Pharmacol. Section Abstract Doc Link 1717819 Disease Relevance 0 Pain Relevance 0.18
These results suggest that the basal expression of proENK and TH mRNA transcription in the adrenal gland seems to be tonically inhibited by de novo protein synthesis.
Negative_regulation (inhibited) of Transcription (transcription) of TH mRNA in adrenal gland
6) Confidence 0.41 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 10825388 Disease Relevance 0 Pain Relevance 0.24
Tyrosine hydroxylase (TH) mRNA levels were increased nearly 7-fold (686 +/- 71%) 24 hr after the first reserpine dose and declined thereafter.
Negative_regulation (declined) of Transcription (levels) of Tyrosine hydroxylase
7) Confidence 0.38 Published 1991 Journal Mol. Pharmacol. Section Abstract Doc Link 1717819 Disease Relevance 0 Pain Relevance 0.18
Both groups of lesioned rats exhibited a similar marked reduction in tyrosine hydroxylase (TH)-mRNA levels, measured by in situ hybridization, in the substantia nigra of the lesioned side.
Negative_regulation (reduction) of Transcription (levels) of TH in substantia nigra associated with substantia nigra
8) Confidence 0.33 Published 2000 Journal Life Sci. Section Abstract Doc Link 10794065 Disease Relevance 0 Pain Relevance 0.16
We observed in these regions that cholecystokinin and tyrosine hydroxylase mRNAs coexisted in the same neurons but not all dopamine cells expressed cholecystokinin mRNA. 6-Hydroxydopamine-induced destruction of mesostriatal dopaminergic neurons resulted in a complete loss of cholecystokinin and tyrosine hydroxylase mRNA expression throughout the substantia nigra pars compacta, indicating that all cholecystokinin expressing cells are 6-hydroxydopamine-sensitive.
Negative_regulation (loss) of Transcription (expression) of tyrosine hydroxylase in dopaminergic neurons associated with dopamine, substantia nigra and cholecystokinin
9) Confidence 0.25 Published 1989 Journal Neuroscience Section Abstract Doc Link 2566954 Disease Relevance 0 Pain Relevance 0.69

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