INT152210

Context Info Confidence 0.63 First Reported 2007 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 4 Disease Relevance 2.64 Pain Relevance 0.30

signal transduction (IFNGR1) plasma membrane (IFNGR1)

Anatomy Link Frequency plasma 1 IFNGR1 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 3 100.00 Inflammation 1 94.00 corticosteroid 1 87.20 Neuritis 1 78.40 antagonist 9 26.72 Neurotransmitter 3 5.00 Pain 3 5.00 Dismenorea 3 5.00 Dopamine 3 5.00 Rheumatism 3 5.00

Disease Link Frequency Relevance Heat Stress 90 99.52 Hypoxia 51 99.38 Bladder Cancer 1 99.02 Cancer 26 94.80 INFLAMMATION 1 94.00 Apoptosis 90 89.40 Breast Cancer 33 84.96 Metastasis 6 83.36 Adenocarcinoma 9 81.84 Optic Neuritis 1 78.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Regulation of other genes, eg. induction of CYP1A1, IFNGR1 and WARS and downregulation of ER?

Positive_regulation (induction) of IFNGR1

1) Confidence 0.63 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.64 Pain Relevance 0

This regulation has already been reported in response to hypoxic stress [57]. mRNAs coding for interferon gamma receptor 1 (IFNGR1) appeared to be upregulated.

Positive_regulation (upregulated) of interferon gamma receptor 1 associated with stress and hypoxia

2) Confidence 0.43 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.66 Pain Relevance 0

This regulation has already been reported in response to hypoxic stress [57]. mRNAs coding for interferon gamma receptor 1 (IFNGR1) appeared to be upregulated.

Positive_regulation (upregulated) of IFNGR1 associated with stress and hypoxia

3) Confidence 0.43 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.66 Pain Relevance 0

Here we report that bladder cancer patients treated with anti-CTLA-4 antibody have increased levels of the Th1 cytokine IFN-gamma detected in plasma samples.

Positive_regulation (increased) of Th1 cytokine IFN-gamma in plasma associated with bladder cancer and cytokine

4) Confidence 0.01 Published 2008 Journal Cancer Immun. Section Abstract Doc Link 18503261 Disease Relevance 0.67 Pain Relevance 0.30

General Comments

This test has worked.