INT152210

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Context Info
Confidence 0.63
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.64
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IFNGR1) plasma membrane (IFNGR1)
Anatomy Link Frequency
plasma 1
IFNGR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 3 100.00 Very High Very High Very High
Inflammation 1 94.00 High High
corticosteroid 1 87.20 High High
Neuritis 1 78.40 Quite High
antagonist 9 26.72 Quite Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Dismenorea 3 5.00 Very Low Very Low Very Low
Dopamine 3 5.00 Very Low Very Low Very Low
Rheumatism 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 90 99.52 Very High Very High Very High
Hypoxia 51 99.38 Very High Very High Very High
Bladder Cancer 1 99.02 Very High Very High Very High
Cancer 26 94.80 High High
INFLAMMATION 1 94.00 High High
Apoptosis 90 89.40 High High
Breast Cancer 33 84.96 Quite High
Metastasis 6 83.36 Quite High
Adenocarcinoma 9 81.84 Quite High
Optic Neuritis 1 78.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regulation of other genes, eg. induction of CYP1A1, IFNGR1 and WARS and downregulation of ER?
Positive_regulation (induction) of IFNGR1
1) Confidence 0.63 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.64 Pain Relevance 0
This regulation has already been reported in response to hypoxic stress [57]. mRNAs coding for interferon gamma receptor 1 (IFNGR1) appeared to be upregulated.
Positive_regulation (upregulated) of interferon gamma receptor 1 associated with stress and hypoxia
2) Confidence 0.43 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.66 Pain Relevance 0
This regulation has already been reported in response to hypoxic stress [57]. mRNAs coding for interferon gamma receptor 1 (IFNGR1) appeared to be upregulated.
Positive_regulation (upregulated) of IFNGR1 associated with stress and hypoxia
3) Confidence 0.43 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.66 Pain Relevance 0
Here we report that bladder cancer patients treated with anti-CTLA-4 antibody have increased levels of the Th1 cytokine IFN-gamma detected in plasma samples.
Positive_regulation (increased) of Th1 cytokine IFN-gamma in plasma associated with bladder cancer and cytokine
4) Confidence 0.01 Published 2008 Journal Cancer Immun. Section Abstract Doc Link 18503261 Disease Relevance 0.67 Pain Relevance 0.30

General Comments

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