INT152252

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.76
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TMED4) endoplasmic reticulum (TMED4) signal transducer activity (TMED4)
Anatomy Link Frequency
band 4
fibroblast 2
TMED4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatosensory cortex 165 100.00 Very High Very High Very High
primary somatosensory cortex 102 86.64 High High
Inflammation 5 75.00 Quite High
Snapping jaw 1 75.00 Quite High
magnetoencephalography 72 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
Transcranial magnetic stimulation 3 5.00 Very Low Very Low Very Low
Thalamus 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 285 99.98 Very High Very High Very High
Disease 1 97.68 Very High Very High Very High
Temporomandibular Joint Disorders 2 92.48 High High
Fibromyalgia 2 86.64 High High
INFLAMMATION 2 75.00 Quite High
Temporomandibular Joint Syndrome 1 75.00 Quite High
Hypercalcemia 1 75.00 Quite High
Congenital Anomalies 6 5.00 Very Low Very Low Very Low
Cognitive Disorder 6 5.00 Very Low Very Low Very Low
Mental Disorders 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PCR amplification and Western blotting were employed to target the expression of estrogen receptors (ERs) in human fibroblast-like synovial and ATDC5 cells.
Positive_regulation (target) of Gene_expression (expression) of ERs in fibroblast
1) Confidence 0.09 Published 2008 Journal Int. J. Mol. Med. Section Abstract Doc Link 18506373 Disease Relevance 0.70 Pain Relevance 0.14
The TFR analysis of the ADHD group showed a strong early ERS in the lower bandwidths (theta and low alpha) and high beta band (25 to 40 Hz), but little power in the midrange (10 to 22 Hz) followed by ERD and a rebound ERS composed of strong activation during the first half of the rebound period and reduced activation in the latter half (Figure 3B).
Positive_regulation (rebound) of Gene_expression (composed) of ERS in band associated with somatosensory cortex and attention deficit hyperactivity disorder
2) Confidence 0.02 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2266931 Disease Relevance 0.36 Pain Relevance 0.31
These group differences were substantiated in the permutation analyses which revealed that adults with ADHD displayed significantly less ERD and significantly shorter beta rebound ERS across both alpha and beta activities (Figure 5D).
Positive_regulation (less) of Gene_expression (displayed) of ERS associated with somatosensory cortex and attention deficit hyperactivity disorder
3) Confidence 0.02 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2266931 Disease Relevance 0.33 Pain Relevance 0.35
The TFR analysis of the ADHD group showed a strong early ERS in the lower bandwidths (theta and low alpha) and high beta band (25 to 40 Hz), but little power in the midrange (10 to 22 Hz) followed by ERD and a rebound ERS composed of strong activation during the first half of the rebound period and reduced activation in the latter half (Figure 3B).
Positive_regulation (activation) of Gene_expression (composed) of ERS in band associated with somatosensory cortex and attention deficit hyperactivity disorder
4) Confidence 0.02 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2266931 Disease Relevance 0.37 Pain Relevance 0.31

General Comments

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