INT152254

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 12.93
Pain Relevance 3.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CSF1R) signal transduction (CSF1R) plasma membrane (CSF1R)
Anatomy Link Frequency
ileum 2
colon 2
epithelial cells 2
intestine 1
CSF1R (Homo sapiens)
Pain Link Frequency Relevance Heat
Fibrositis 288 100.00 Very High Very High Very High
Crohn's disease 362 99.62 Very High Very High Very High
cytokine 52 86.88 High High
Inflammation 87 84.36 Quite High
Snapping jaw 2 75.00 Quite High
rheumatoid arthritis 32 74.56 Quite High
nud 1 72.64 Quite High
Pain 32 67.04 Quite High
Central nervous system 2 65.12 Quite High
chronic pain syndrome 1 51.04 Quite High
Disease Link Frequency Relevance Heat
Fibromyalgia 311 100.00 Very High Very High Very High
Ovarian Cancer 104 99.92 Very High Very High Very High
Disease 370 99.62 Very High Very High Very High
Familial Mediterranean Fever 50 98.52 Very High Very High Very High
Disease Susceptibility 83 95.08 Very High Very High Very High
Colon Cancer 21 94.80 High High
Transitional Cell Carcinoma 2 93.44 High High
Myelodysplastic Syndromes 9 91.48 High High
Syndrome 28 91.16 High High
Acute Myeloid Leukemia 9 90.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of estrogen was investigated through the expression of RANKL, osteoprotegerin (OPG), M-CSF/CSF-1 and c-fms.
Spec (investigated) Gene_expression (expression) of c-fms associated with fibromyalgia
1) Confidence 0.75 Published 2008 Journal Int. J. Mol. Med. Section Abstract Doc Link 18506373 Disease Relevance 0.74 Pain Relevance 0.15
We showed expression of M-CSF/ CSF-1 and c-fms, with time-dependent increase in both after the addition of estrogen.
Gene_expression (expression) of c-fms associated with fibromyalgia
2) Confidence 0.75 Published 2008 Journal Int. J. Mol. Med. Section Abstract Doc Link 18506373 Disease Relevance 0.75 Pain Relevance 0.15
Although expression of CSF1R has been detected in epithelial cells of other organs, the expression of CSF1R in the intestine has not been well documented [15-18].
Gene_expression (expression) of CSF1R in epithelial cells
3) Confidence 0.71 Published 2004 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC428583 Disease Relevance 0.75 Pain Relevance 0.40
Although expression of CSF1R has been detected in epithelial cells of other organs, the expression of CSF1R in the intestine has not been well documented [15-18].
Gene_expression (expression) of CSF1R in epithelial cells
4) Confidence 0.71 Published 2004 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC428583 Disease Relevance 0.73 Pain Relevance 0.37
There is a paucity of literature regarding the expression of the CSF1R protein in the intestine despite documentation of its presence in the epithelium of a variety of other tissues including breast, ovary, endometrium, lung and prostate [15-18,28].
Gene_expression (expression) of CSF1R protein in intestine
5) Confidence 0.71 Published 2004 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC428583 Disease Relevance 0.69 Pain Relevance 0.23
Using microarray analysis to examine gene expression in endoscopic colonic biopsies from patients with newly diagnosed, untreated Crohn's disease, we identified an overexpressed gene on 5q33, CSF1R (unpublished data).
Gene_expression (overexpressed) of CSF1R associated with crohn's disease and disease
6) Confidence 0.62 Published 2004 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC428583 Disease Relevance 0.85 Pain Relevance 0.46
We also show, using immunohistochemistry, that the CSF1R protein is expressed in the superficial epithelium of the ileum and colon.
Gene_expression (expressed) of CSF1R protein in colon
7) Confidence 0.55 Published 2004 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC428583 Disease Relevance 0.45 Pain Relevance 0.25
The CSF1R protein is expressed in the superficial epithelium of the ileum and colon
Gene_expression (expressed) of CSF1R protein in colon
8) Confidence 0.55 Published 2004 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC428583 Disease Relevance 0.24 Pain Relevance 0.12
Using gene expression analysis, we identified a differentially expressed gene on 5q33, the colony stimulating factor 1 receptor (CSF1R) gene, and hypothesized that it is a Crohn's susceptibility gene.
Gene_expression (expressed) of CSF1R
9) Confidence 0.55 Published 2004 Journal J Immune Based Ther Vaccines Section Abstract Doc Link PMC428583 Disease Relevance 0.39 Pain Relevance 0.15
Two studies [9,10] suggested that FMS segregates within families in an autosomal dominant mode of inheritance.
Gene_expression (segregates) of FMS associated with fibrositis
10) Confidence 0.49 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779444 Disease Relevance 1.62 Pain Relevance 0.75
These results support our diagnosis of FMS in this cohort, rather than variant FMF.
Gene_expression (diagnosis) of FMS associated with familial mediterranean fever and fibrositis
11) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 0.96 Pain Relevance 0.13
Thus, the parents serve as “controls” for the FMS affecteds.
Gene_expression (affecteds) of FMS associated with fibrositis
12) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 0.83 Pain Relevance 0.25
Furthermore, Yang et al., reported that the G-CSFR was expressed in 59% of CRCs [16].
Gene_expression (expressed) of G-CSFR
13) Confidence 0.22 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2474610 Disease Relevance 0.97 Pain Relevance 0
Savarese et al., reported that 56.5% of primary ovarian carcinomas co-expressed G-CSF and the G-CSF receptor (G-CSFR); potential autocrine and/or paracrine loops involving G-CSF and its receptor occur in over 90% of primary ovarian carcinomas [15].
Gene_expression (expressed) of G-CSFR associated with ovarian cancer
14) Confidence 0.19 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2474610 Disease Relevance 0.91 Pain Relevance 0
The CSF1R protein is expressed in the superficial epithelium of the ileum and colon
Gene_expression (expressed) of CSF1R protein in ileum
15) Confidence 0.19 Published 2004 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC428583 Disease Relevance 0.24 Pain Relevance 0.12
We also show, using immunohistochemistry, that the CSF1R protein is expressed in the superficial epithelium of the ileum and colon.
Gene_expression (expressed) of CSF1R protein in ileum
16) Confidence 0.19 Published 2004 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC428583 Disease Relevance 0.45 Pain Relevance 0.25
Sunitinib (SUN) is an orally bioavailable small molecule that inhibits multiple tyrosine kinases including all the PDGF receptors and VEGF receptors, as well as c-kit, RET, CSF-1R, and flt-3.
Gene_expression (receptors) of CSF-1R
17) Confidence 0.01 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2804796 Disease Relevance 1.36 Pain Relevance 0.04

General Comments

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