INT152388

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.14
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NFKB1) mitochondrion (NFKB1) Golgi apparatus (OPRM1)
endoplasmic reticulum (OPRM1) signal transducer activity (OPRM1) cytoplasm (NFKB1)
NFKB1 (Homo sapiens)
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 4 98.68 Very High Very High Very High
antagonist 3 96.24 Very High Very High Very High
MU agonist 2 94.72 High High
narcan 3 84.36 Quite High
opioid receptor 3 75.00 Quite High
Morphine 1 74.72 Quite High
agonist 1 74.32 Quite High
Disease Link Frequency Relevance Heat
Breast Cancer 1 75.00 Quite High
Adenocarcinoma 1 64.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We propose that the opioid-induced regulation of MOR mRNA expression is mediated by reduced binding of the transcription factors NFkappaB and AP-1 to the promoter region on the MOR gene.
NFkappaB Binding (binding) of MOR gene associated with opioid
1) Confidence 0.04 Published 2008 Journal Biochem. Cell Biol. Section Abstract Doc Link 18523482 Disease Relevance 0.14 Pain Relevance 0.94

General Comments

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