INT152390

Context Info Confidence 0.13 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.14 Pain Relevance 0.94

nucleoplasm (JUN) nuclear chromosome (JUN) aging (JUN) Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) DNA binding (JUN)

JUN (Homo sapiens) OPRM1 (Homo sapiens)

Pain Link Frequency Relevance Heat Opioid 4 98.84 antagonist 3 96.56 MU agonist 2 95.04 narcan 3 84.68 Morphine 1 75.04 opioid receptor 3 75.00 agonist 1 74.64

Disease Link Frequency Relevance Heat Breast Cancer 1 75.00 Adenocarcinoma 1 64.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We propose that the opioid-induced regulation of MOR mRNA expression is mediated by reduced binding of the transcription factors NFkappaB and AP-1 to the promoter region on the MOR gene.

Negative_regulation (reduced) of AP-1 Binding (binding) of MOR gene associated with opioid

1) Confidence 0.13 Published 2008 Journal Biochem. Cell Biol. Section Abstract Doc Link 18523482 Disease Relevance 0.14 Pain Relevance 0.94

General Comments

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