INT152622

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Context Info
Confidence 0.14
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 1.19
Pain Relevance 3.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (MAPK4) cell cycle (MAPK4) cytoplasm (MAPK4)
Anatomy Link Frequency
myocardium 3
nucleus 1
hearts 1
MAPK4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 240 100.00 Very High Very High Very High
ischemia 84 100.00 Very High Very High Very High
aspirin 200 98.60 Very High Very High Very High
antagonist 24 92.00 High High
adenocard 108 90.24 High High
Angina 3 87.76 High High
agonist 24 68.88 Quite High
tolerance 6 60.80 Quite High
Inflammation 8 57.04 Quite High
Pain 12 34.76 Quite Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 84 100.00 Very High Very High Very High
Stress 7 99.60 Very High Very High Very High
Cv General 3 Under Development 3 87.76 High High
Atherosclerosis 12 80.92 Quite High
Shock 12 73.12 Quite High
Apoptosis 18 64.52 Quite High
Coronary Artery Disease 1 60.92 Quite High
INFLAMMATION 22 57.04 Quite High
Aging 2 52.72 Quite High
Death 2 42.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In very old myocardium, higher levels of active p38MAPK in atrial trabeculae after ischemia pointed at an increased cellular stress, which was even more pronounced after post-ischemic reperfusion.
Positive_regulation (increased) of p38MAPK in myocardium associated with stress and ischemia
1) Confidence 0.14 Published 2008 Journal Exp. Gerontol. Section Abstract Doc Link 18556165 Disease Relevance 0.68 Pain Relevance 0.28
Activation of p38MAPK has also been connected to preconditioning in the rabbit heart, [32] however the relationship could not be established in rat [33] and pig [34] hearts.
Positive_regulation (Activation) of p38MAPK in hearts
2) Confidence 0.12 Published 2002 Journal BMC Physiol Section Body Doc Link PMC117790 Disease Relevance 0 Pain Relevance 0.25
Our results have shown that activation of p38MAPK is a crucial step in the transduction pathway of preconditioning in the human myocardium.
Positive_regulation (activation) of p38MAPK in myocardium
3) Confidence 0.12 Published 2002 Journal BMC Physiol Section Body Doc Link PMC117790 Disease Relevance 0 Pain Relevance 0.26
PKC may then translocate to various cellular sites including the mitochondria, sarcolemma and intercalated discs, and nucleus, a phenomena that may involve specific PKC isoforms, where p38MAPK will be activated.
Positive_regulation (activated) of p38MAPK in nucleus associated with kinase c
4) Confidence 0.12 Published 2002 Journal BMC Physiol Section Body Doc Link PMC117790 Disease Relevance 0 Pain Relevance 0.34
It is still unknown whether the activation of p38MAPK is the last step of the transduction cascade that phosphorylates the end-effector and whether there is a simple or multiple effectors and their location. p38MAPK can phosphorylate a wide range of proteins, some of which may be potential candidates for end-effectors of preconditioning.
Spec (whether) Positive_regulation (activation) of p38MAPK
5) Confidence 0.08 Published 2002 Journal BMC Physiol Section Body Doc Link PMC117790 Disease Relevance 0.13 Pain Relevance 0.26
Sequence of activation of PKC, p38MAPK and mitoKATP channels (Study 3)
Positive_regulation (activation) of p38MAPK associated with kinase c
6) Confidence 0.08 Published 2002 Journal BMC Physiol Section Body Doc Link PMC117790 Disease Relevance 0 Pain Relevance 0.51
Opening of mitoKATP channels and activation of PKC and p38MAPK are obligatory steps in the signal transduction cascade of IP and PP of the human myocardium with PKC activation being downstream of the opening of mitoKATP channels and upstream of p38MAPK activation.



Positive_regulation (activation) of p38MAPK in myocardium associated with kinase c
7) Confidence 0.08 Published 2002 Journal BMC Physiol Section Abstract Doc Link PMC117790 Disease Relevance 0.06 Pain Relevance 0.32
However, the activation of p38MAPK was independent of TGF-?
Positive_regulation (activation) of p38MAPK
8) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842433 Disease Relevance 0.20 Pain Relevance 0.40
1 and subsequent p38MAPK activation.
Positive_regulation (activation) of p38MAPK
9) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842433 Disease Relevance 0.11 Pain Relevance 0.48

General Comments

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