INT152646

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.54
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF7) nucleoplasm (IRF7) plasma membrane (IRF7)
nucleus (IRF7) cytoplasm (IRF7)
Anatomy Link Frequency
T-cell 4
IRF7 (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 1 74.84 Quite High
Pain 1 74.44 Quite High
Inflammation 52 55.40 Quite High
cytokine 8 21.64 Low Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 11 100.00 Very High Very High Very High
Necrosis 1 100.00 Very High Very High Very High
Skin Cancer 1 100.00 Very High Very High Very High
Cancer 1 100.00 Very High Very High Very High
Infection 9 92.04 High High
Adhesions 3 91.76 High High
Wound Healing 2 91.52 High High
Myalgia 1 76.56 Quite High
Leukopenia 1 75.68 Quite High
Exanthema 1 75.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased expression of the type I IFN response genes for tumour necrosis factor-related apoptosis-inducing ligand (TRAIL), melanoma-derived antigen 5 (MDA-5), IFN-gamma-inducible protein 10 (IP-10), galectin 3 soluble binding protein (LGals3BP) and IFN response factor 7 (IRF7) was confirmed by quantitative RT-PCR.
Positive_regulation (Increased) of Gene_expression (expression) of IRF7 associated with necrosis, cancer, skin cancer and apoptosis
1) Confidence 0.37 Published 2008 Journal J. Gen. Virol. Section Abstract Doc Link 18559930 Disease Relevance 1.65 Pain Relevance 0.15
IRF-7 is essential for the induction of a systemic type-I Interferon (IFN-alpha/beta) response for innate antiviral immunity as well as the induction of a CD8+ T-cell response in adaptive immunity [31].
Positive_regulation (response) of Gene_expression (essential) of IRF-7 in T-cell
2) Confidence 0.07 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2491649 Disease Relevance 0.44 Pain Relevance 0.03
IRF-7 is essential for the induction of a systemic type-I Interferon (IFN-alpha/beta) response for innate antiviral immunity as well as the induction of a CD8+ T-cell response in adaptive immunity [31].
Positive_regulation (induction) of Gene_expression (essential) of IRF-7 in T-cell
3) Confidence 0.07 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2491649 Disease Relevance 0.44 Pain Relevance 0.03

General Comments

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