INT152864

Context Info Confidence 0.52 First Reported 2008 Last Reported 2010 Negated 3 Speculated 0 Reported most in Abstract Documents 2 Total Number 4 Disease Relevance 0 Pain Relevance 1.66

extracellular space (S100b) nucleus (S100b) cytoplasm (S100b)

Anatomy Link Frequency astrocyte 2 S100b (Rattus norvegicus)

Pain Link Frequency Relevance Heat sSRI 3 100.00 tetrodotoxin 9 99.80 sodium channel 3 99.34 fluoxetine 4 99.18 Calcium channel 3 97.66 Serotonin 4 95.84 Glutamate 3 94.72 antidepressant 2 87.88

Disease Link Frequency Relevance Heat Depressive Disorder 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Neither inhibition of nitric oxide (NO) synthase by L-NAME nor addition of the NO donors sodium nitroprussid (SNP) or hydroxylamine (HA) to the medium altered basal S100B release.

Neg (nor) Regulation (altered) of Localization (release) of S100B

1) Confidence 0.52 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19823932 Disease Relevance 0 Pain Relevance 0.22

Moreover, individual inhibition of PKC, PLA(2) or PLC all failed to attenuate the S100B release determined under control condition or enhanced by either OGD or REO.

Neg (failed) Regulation (attenuate) of Localization (release) of S100B

2) Confidence 0.38 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19823932 Disease Relevance 0 Pain Relevance 0.30

Blockade of calcium channels with verapamil, chelating the Ca(+2) ions with BAPTA or blockade of sodium channels with tetrodotoxin (TTX) did not alter OGD- and REO-induced S100B release.

Neg (not) Regulation (alter) of Localization (release) of S100B associated with tetrodotoxin, calcium channel and sodium channel

3) Confidence 0.26 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19823932 Disease Relevance 0 Pain Relevance 0.41

Here, we measured S100B secretion directly in hippocampal astrocyte cultures and hippocampal slices exposed to fluoxetine and observed a significant increment of S100B release in the presence of this SSRI, apparently dependent on protein kinase A (PKA).

Regulation (dependent) of Localization (release) of S100B in astrocyte associated with ssri and fluoxetine

4) Confidence 0.26 Published 2008 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 18582527 Disease Relevance 0 Pain Relevance 0.73

General Comments

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