INT152865

Context Info Confidence 0.68 First Reported 2008 Last Reported 2010 Negated 1 Speculated 0 Reported most in Abstract Documents 3 Total Number 7 Disease Relevance 0 Pain Relevance 2.53

extracellular space (S100b) nucleus (S100b) cytoplasm (S100b)

Anatomy Link Frequency astrocyte 4 S100b (Rattus norvegicus)

Pain Link Frequency Relevance Heat fluoxetine 8 99.84 tetrodotoxin 15 99.42 sSRI 6 99.00 sodium channel 5 98.96 Serotonin 8 98.16 Calcium channel 5 97.28 Glutamate 5 94.72 antidepressant 4 88.40

Disease Link Frequency Relevance Heat Depressive Disorder 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Additionally, calcium and sodium currents that are sensitive to verapamil and TTX, respectively, are unlikely to contribute to the enhanced S100B release observed under these conditions.

Positive_regulation (contribute) of Localization (release) of S100B associated with tetrodotoxin

1) Confidence 0.68 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19823932 Disease Relevance 0 Pain Relevance 0.38

Incubation of rat cortical slices in a medium that was not containing oxygen and glucose (oxygen-glucose deprivation, OGD) caused a 200% increase in the release of S100B.

Positive_regulation (caused) of Localization (release) of S100B

2) Confidence 0.59 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19823932 Disease Relevance 0 Pain Relevance 0

Here, we measured S100B secretion directly in hippocampal astrocyte cultures and hippocampal slices exposed to fluoxetine and observed a significant increment of S100B release in the presence of this SSRI, apparently dependent on protein kinase A (PKA).

Positive_regulation (increment) of Localization (release) of S100B in astrocyte associated with ssri and fluoxetine

3) Confidence 0.49 Published 2008 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 18582527 Disease Relevance 0 Pain Relevance 0.71

Blockade of calcium channels with verapamil, chelating the Ca(+2) ions with BAPTA or blockade of sodium channels with tetrodotoxin (TTX) did not alter OGD- and REO-induced S100B release.

Neg (not) Positive_regulation (induced) of Localization (release) of S100B associated with tetrodotoxin, calcium channel and sodium channel

4) Confidence 0.46 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19823932 Disease Relevance 0 Pain Relevance 0.41

Additionally, calcium and sodium currents that are sensitive to verapamil and TTX, respectively, are unlikely to contribute to the enhanced S100B release observed under these conditions.

Positive_regulation (enhanced) of Localization (release) of S100B associated with tetrodotoxin

5) Confidence 0.46 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19823932 Disease Relevance 0 Pain Relevance 0.38

Secretion of S100B, an astrocyte-derived neurotrophic protein, is stimulated by fluoxetine via a mechanism independent of serotonin.

Positive_regulation (stimulated) of Localization (Secretion) of S100B in astrocyte associated with serotonin and fluoxetine

6) Confidence 0.45 Published 2008 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Title Doc Link 18582527 Disease Relevance 0 Pain Relevance 0.65

Incubation of rat cortical slices in a medium that was not containing oxygen and glucose (oxygen-glucose deprivation, OGD) caused a 200% increase in the release of S100B.

Positive_regulation (increase) of Localization (release) of S100B

7) Confidence 0.40 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19823932 Disease Relevance 0 Pain Relevance 0

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