INT152930

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Context Info
Confidence 0.52
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 5
Disease Relevance 3.52
Pain Relevance 3.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Cldn2) plasma membrane (Cldn2)
Cldn2 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 55 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 35 99.18 Very High Very High Very High
Apoptosis 5 98.40 Very High Very High Very High
INFLAMMATION 5 97.36 Very High Very High Very High
Metastasis 5 93.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the current study, we have systematically examined the effects of various NSAIDs on the expression of various TJ proteins and have found that NSAIDs specifically and drastically inhibit the expression of claudin-2.
Negative_regulation (inhibit) of Gene_expression (expression) of claudin-2 associated with cinod
1) Confidence 0.52 Published 2008 Journal Carcinogenesis Section Abstract Doc Link 18586689 Disease Relevance 0.68 Pain Relevance 0.79
NSAIDs suppress the expression of claudin-2 to promote invasion activity of cancer cells.
Negative_regulation (suppress) of Gene_expression (expression) of claudin-2 associated with cancer and cinod
2) Confidence 0.52 Published 2008 Journal Carcinogenesis Section Title Doc Link 18586689 Disease Relevance 0.59 Pain Relevance 0.66
In contrast, neither cell growth nor apoptosis induced by lack of anchorage of cancer cells was affected by overexpression or suppression of expression of claudin-2.
Negative_regulation (suppression) of Gene_expression (expression) of claudin-2 associated with cancer and apoptosis
3) Confidence 0.38 Published 2008 Journal Carcinogenesis Section Abstract Doc Link 18586689 Disease Relevance 0.73 Pain Relevance 0.84
Overexpression or suppression of claudin-2 expression caused stimulation or inhibition, respectively, of the invasion and migration activity of cancer cells.
Negative_regulation (suppression) of Gene_expression (expression) of claudin-2 associated with cancer
4) Confidence 0.38 Published 2008 Journal Carcinogenesis Section Abstract Doc Link 18586689 Disease Relevance 0.70 Pain Relevance 0.79
These results suggest that inhibition of claudin-2 expression by NSAIDs contributes to NSAID-dependent inhibition of invasion of cancer cells in vitro and that it may be involved in the chemopreventive effects of NSAIDs by inhibiting metastasis in vivo.
Negative_regulation (inhibition) of Gene_expression (expression) of claudin-2 associated with cancer, cinod and metastasis
5) Confidence 0.38 Published 2008 Journal Carcinogenesis Section Abstract Doc Link 18586689 Disease Relevance 0.81 Pain Relevance 0.84

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