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Context Info
Confidence 0.90
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.46
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SPINK1)
SPINK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 14 94.00 High High
Chronic pancreatitis 100 93.56 High High
abdominal pain 3 71.40 Quite High
Pain 6 5.60 Low Low
Inflammation 6 5.00 Very Low Very Low Very Low
Bile 6 5.00 Very Low Very Low Very Low
Pain management 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Lasting pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cystic Fibrosis 13 94.56 High High
Pancreatitis 136 93.56 High High
Nutritional Deficiencies 2 78.68 Quite High
Disease 25 76.08 Quite High
Calcification 7 75.00 Quite High
Diabetes Mellitus 9 73.72 Quite High
Pancreatic Cancer 16 71.96 Quite High
Abdominal Pain 3 71.40 Quite High
Nicotine Addiction 3 69.64 Quite High
Alcoholic Pancreatitis 3 34.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is explainable by the fact that SPINK1 is degraded by trypsin [35].
Protein_catabolism (degraded) of SPINK1
1) Confidence 0.90 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.98 Pain Relevance 0.65
These include alterations in genes coding for trypsinogens, the most abundant digestive enzymes (PRSS1 and PRSS2), the trypsin inhibitor (SPINK1) and the trypsin-degrading enzyme, chymotrypsinogen C (CTRC).
Protein_catabolism (degrading) of SPINK1
2) Confidence 0.39 Published 2008 Journal Rev Endocr Metab Disord Section Abstract Doc Link 18604651 Disease Relevance 1.48 Pain Relevance 0.45

General Comments

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