INT153269

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Context Info
Confidence 0.48
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 8.87
Pain Relevance 4.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ccl3) extracellular space (Ccl3) extracellular region (Ccl3)
intracellular (Ccl3) cytoskeleton organization (Ccl3) kinase activity (Ccl3)
Anatomy Link Frequency
macrophages 2
saliva 2
T cell 2
paw 1
Ccl3 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 311 100.00 Very High Very High Very High
Inflammation 238 100.00 Very High Very High Very High
ischemia 45 100.00 Very High Very High Very High
Multiple sclerosis 190 98.40 Very High Very High Very High
allodynia 1 98.24 Very High Very High Very High
Angina 4 97.80 Very High Very High Very High
Thermal hyperalgesia 1 97.74 Very High Very High Very High
cytokine 91 96.00 Very High Very High Very High
antagonist 41 94.16 High High
Hyperalgesia 7 90.48 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 260 100.00 Very High Very High Very High
Coronary Artery Disease 3 100.00 Very High Very High Very High
Multiple Sclerosis 217 98.40 Very High Very High Very High
Neuropathic Pain 2 98.24 Very High Very High Very High
Respiratory Syncytial Virus 103 97.86 Very High Very High Very High
Cv General 3 Under Development 4 97.80 Very High Very High Very High
Hyperalgesia 8 97.74 Very High Very High Very High
Pulmonary Disease 109 97.56 Very High Very High Very High
Myocardial Infarction 5 95.08 Very High Very High Very High
Infection 40 93.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In support of a direct association with cardiac ischemia CCL3 levels were also seen to be elevated in patients with UAP at baseline and significantly down-regulated after 180 days (P<0.001).
CCL3 Binding (association) of associated with angina, coronary artery disease and ischemia
1) Confidence 0.48 Published 2008 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 18619972 Disease Relevance 1.43 Pain Relevance 0.69
GRK2(+/-) mice with an approximately 50% reduction in GRK2 developed increased and markedly prolonged thermal hyperalgesia and mechanical allodynia after carrageenan-induced paw inflammation or after intraplantar injection of the GPCR-binding chemokine CCL3.
CCL3 Binding (binding) of in paw associated with chemokine, inflammation, allodynia and thermal hyperalgesia
2) Confidence 0.35 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20147541 Disease Relevance 0.95 Pain Relevance 0.99
The CCL3 and CCR5 interaction promotes polarization towards the TH1 subtype.
CCL3 Binding (interaction) of
3) Confidence 0.29 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.80 Pain Relevance 0.46
Also, CCR1 deficient mice had reduced content of the CCR1 ligands CCL3 (MIP-1alpha) and CCL5 (RANTES).
CCL3 Binding (ligands) of
4) Confidence 0.28 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 0.67 Pain Relevance 0.66
CCL5, CCL3, and CXCL8 or the control protein, equine myoglobin, were diluted to 0.1 ?
CCL3 Binding (diluted) of
5) Confidence 0.25 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2526197 Disease Relevance 0 Pain Relevance 0.04
We analyzed the ability of saliva from Rhipicephalus sanguineus (common brown dog tick) to inhibit the binding of the I125-labeled chemokines CCL2, CCL5, and CXCL8, as well as CCL3, to their respective receptors using a scintillation proximity assay.
CCL3 Spec (analyzed) Binding (binding) of in saliva associated with chemokine
6) Confidence 0.24 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2526197 Disease Relevance 0.60 Pain Relevance 0.45
Our own analyses of tick saliva harvested during feeding also demonstrated the presence of molecules that bound to CXCL8, CCL3, and CCL5.
CCL3 Binding (bound) of in saliva
7) Confidence 0.24 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2526197 Disease Relevance 0.37 Pain Relevance 0.26
CB exposure also enhanced RSV-induced airway hyperresponsiveness to methacholine, bronchoalveolar lavage (BAL) total protein, and virus-associated chemokines monocyte chemoattractant protein (MCP-1), macrophage inflammatory protein (MIP-1 alpha), and regulated upon activation, normal T cell expressed and secreted (RANTES).
macrophage inflammatory protein Binding (associated) of in T cell associated with chemokine, inflammation and respiratory syncytial virus
8) Confidence 0.15 Published 2010 Journal Respir Res Section Body Doc Link PMC2841591 Disease Relevance 1.54 Pain Relevance 0.23
However, these drugs are unable to significantly reduce macrophage chemoattraction because they inhibit only CCL3, but not CCL4 binding to CCR5, thus probably not being of particular interest for COPD treatment.


CCL3 Binding (binding) of in macrophage associated with pulmonary disease
9) Confidence 0.12 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 0.67 Pain Relevance 0.26
We found that TCF2 upregulates the CC chemokine receptor 1 (CCR1) a molecule expressed on macrophages and T cells; in MS plaques, numerous CCR1-positive infiltrating macrophages and microglial cells, associated with CCL3, were found [2] and CCR1 has been associated with newly infiltrating monocytes in MS lesions [32].
CCL3 Binding (associated) of in T cells associated with chemokine and multiple sclerosis
10) Confidence 0.11 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 0.92 Pain Relevance 0.33
We found that TCF2 upregulates the CC chemokine receptor 1 (CCR1) a molecule expressed on macrophages and T cells; in MS plaques, numerous CCR1-positive infiltrating macrophages and microglial cells, associated with CCL3, were found [2] and CCR1 has been associated with newly infiltrating monocytes in MS lesions [32].
CCL3 Binding (associated) of in macrophages associated with chemokine and multiple sclerosis
11) Confidence 0.04 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 0.92 Pain Relevance 0.33

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