INT15375

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Context Info
Confidence 0.65
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 18.50
Pain Relevance 3.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (AXL) signal transduction (AXL) plasma membrane (AXL)
Anatomy Link Frequency
endometrium 2
thyroid 1
blood vessels 1
epithelial cells 1
lung 1
AXL (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 972 99.84 Very High Very High Very High
rheumatoid arthritis 121 99.84 Very High Very High Very High
Inflammation 40 99.56 Very High Very High Very High
metalloproteinase 21 95.24 Very High Very High Very High
Dismenorea 10 87.12 High High
Chronic pancreatitis 10 77.92 Quite High
palliative 1 74.96 Quite High
Somatostatin 5 67.76 Quite High
pain pelvic 18 52.92 Quite High
addiction 9 48.32 Quite Low
Disease Link Frequency Relevance Heat
Cancer 540 100.00 Very High Very High Very High
Adhesions 40 100.00 Very High Very High Very High
Endometriosis 1242 99.84 Very High Very High Very High
Rheumatoid Arthritis 121 99.84 Very High Very High Very High
Pancreatic Cancer 67 99.84 Very High Very High Very High
Islet Cell Adenoma 58 99.84 Very High Very High Very High
Papillomavirus Infection 3 99.84 Very High Very High Very High
INFLAMMATION 37 99.56 Very High Very High Very High
Leukemia 11 99.16 Very High Very High Very High
Hypoxia 17 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, it is possible that overexpression of AXL and GAS6 is a main cause for the activation of the PI3K-Akt pathway in endometriosis.
Gene_expression (overexpression) of AXL associated with endometriosis
1) Confidence 0.65 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.79 Pain Relevance 0.24
Co-overexpression of AXL with Gas6 has also been reported in several types of tumors including ovarian cancer [45], and may therefore have an important role in uncontrolled cell growth/proliferation.
Gene_expression (overexpression) of AXL associated with cancer and ovarian cancer
2) Confidence 0.65 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.91 Pain Relevance 0.28
Overexpression of both AXL and GAS6 in ovarian endometriosis has previously been demonstrated using RT-PCR analysis and IHC [44].
Gene_expression (Overexpression) of AXL associated with endometriosis
3) Confidence 0.65 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.91 Pain Relevance 0.27
AXL expression is also elevated in leukemia, melanoma, prostate, colon, endometrial, and thyroid cancers[29]–[32].
Gene_expression (expression) of AXL in thyroid associated with thyroid neoplasm, leukemia and skin cancer
4) Confidence 0.63 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 1.14 Pain Relevance 0.03
Although, the comparison of gene expression profiles between endometriosis and normal endometrium was done for the proliferative phase, AXL, SHC1, and ACTN4 (discussed below) were also overexpressed during secretory phase in ovarian endometriosis.
Gene_expression (overexpressed) of AXL in endometrium associated with endometriosis
5) Confidence 0.57 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 1.18 Pain Relevance 0.42
Similar to what we observed for AXL, SHC1 was found consistently elevated in the studied endometriotic samples.
Gene_expression (observed) of AXL associated with endometriosis
6) Confidence 0.56 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.78 Pain Relevance 0.19
As overexpression of AXL and SHC1 theoretically activates both PI3K-Akt and MAPK pathways, dysregulation of these genes in human endometriosis may correspond to oncogenic activation of K-ras or biallelic losses of Pten in the mouse model of the disease.
Gene_expression (overexpression) of AXL associated with endometriosis and disease
7) Confidence 0.50 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 1.10 Pain Relevance 0.38
In human endometriosis, the PI3K-Akt and MAPK signaling pathways may be activated via overexpression of AXL and SHC1, respectively.
Gene_expression (overexpression) of AXL associated with endometriosis
8) Confidence 0.50 Published 2008 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2615013 Disease Relevance 0.93 Pain Relevance 0.34
Our data show that AXL and SHC1 are differentially expressed in endometriosis implicating the PI3K and MAPK pathways in this disease.
Gene_expression (expressed) of AXL associated with endometriosis and disease
9) Confidence 0.50 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 1.18 Pain Relevance 0.42
AXL, SHC1, and ACTN4, all shown to be overexpressed in endometriotic epithelial cells by SAGE, were selected for IHC validation.
Gene_expression (overexpressed) of AXL in epithelial cells associated with endometriosis
10) Confidence 0.50 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.71 Pain Relevance 0.26
These include the oncogenes JAZF1, AXL, ABL2; tumor suppressors RASD1, PTPRO, TFAP2A, CDKN1C; and genes involved in proteolysis or cell-adhesion such as WASF2, and PAPPA.



Gene_expression (adhesion) of AXL associated with cancer and adhesions
11) Confidence 0.44 Published 2007 Journal Cancer Informatics Section Abstract Doc Link PMC2675843 Disease Relevance 0.95 Pain Relevance 0
Our analysis identified additional genes, including AXL, MFAB, and AXIN2, whose elevated expression in islet cell tumors suggests signal transduction pathways important in their development.
Gene_expression (expression) of AXL associated with islet cell adenoma
12) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 1.59 Pain Relevance 0
They include carbonic anyhdrase IX, which is the RCC associated antigen G250 and is induced in many cancer types, hypoxia induced gene ADORA3, potentially oncogenic AXL gene which causes transformation when overexpressed in NIH 3T3 cells, and vitamin D receptor (VDR, up-regulated), which was found to be over-expressed in pancreatic cell lines (Albrechtsson et al. 2003) and is down-regulated by resveratrol compound (Shi et al. 2004) in RCC cell lines, which acts as a chemopreventive agent for RCC and other types of cancers.
Gene_expression (overexpressed) of AXL gene associated with hypoxia, cancer and renal cancer
13) Confidence 0.34 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.14 Pain Relevance 0
Premalignant and malignant lesions of the cervix uteri and endometrium were analyzed for the presence of human papillomavirus (HPV) DNA and c-myc or c-erbB2/neu oncogene expression.
Gene_expression (expression) of oncogene in endometrium associated with papillomavirus infection and malignant neoplastic disease
14) Confidence 0.30 Published 1991 Journal Verh Dtsch Ges Pathol Section Abstract Doc Link 1724842 Disease Relevance 0.92 Pain Relevance 0.09
One of these tyrosine kinases, Axl, has been detected in RA synovia, localising to the capillary endothelium, to vascular smooth muscle cells of blood vessels and to other cells [93].
Gene_expression (detected) of Axl in blood vessels associated with rheumatoid arthritis
15) Confidence 0.20 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 0.77 Pain Relevance 0.23
These data suggest that there is abnormal expression of c-erb B-2 oncogene in nearly 20 per cent of cases although mutational activation of this gene is not seen in human pancreatic adenocarcinoma.
Gene_expression (expression) of oncogene associated with adenocarcinoma
16) Confidence 0.12 Published 1990 Journal J. Pathol. Section Abstract Doc Link 2202801 Disease Relevance 0.47 Pain Relevance 0.11
The expression of proto-oncogene c-jun in human pancreatic cancer.
Gene_expression (expression) of oncogene associated with pancreatic cancer
17) Confidence 0.06 Published 1999 Journal Anticancer Res. Section Title Doc Link 10216507 Disease Relevance 0.63 Pain Relevance 0.21
The aims of this study were to evaluate a) the expression of c-jun oncogene in pancreatic cancer b) its relation with tumor histological features.
Gene_expression (expression) of oncogene associated with cancer and pancreatic cancer
18) Confidence 0.05 Published 1999 Journal Anticancer Res. Section Abstract Doc Link 10216507 Disease Relevance 0.53 Pain Relevance 0.16
MLT has been shown to exert anticancer activity through several biological mechanisms: antiproliferative action, stimulation of anticancer immunity, modulation of oncogene expression, and anti-inflammatory, anti-oxidant and anti-angiogenic effects.
Gene_expression (expression) of oncogene associated with inflammation
19) Confidence 0.02 Published 2002 Journal Support Care Cancer Section Abstract Doc Link 11862501 Disease Relevance 0.32 Pain Relevance 0.12
It is conceivable that such an approach, coupled with a greater understanding from multiple tumor datasets, could be replaced by the absolute quantification of oncogene expression as a means to determine clinical relevance.
Gene_expression (expression) of oncogene associated with cancer
20) Confidence 0.02 Published 2010 Journal Genome Biol Section Body Doc Link PMC2945784 Disease Relevance 0.89 Pain Relevance 0

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