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Latest revision as of 08:25, 22 September 2012

Context Info
Confidence 0.36
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 27
Total Number 28
Disease Relevance 33.83
Pain Relevance 5.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DCPS) mitochondrion (DCPS) nucleolus (DCPS)
nucleus (DCPS) cytoplasm (DCPS)
Anatomy Link Frequency
blood 11
DCs 3
neck 1
pancreas 1
head 1
DCPS (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 28 99.60 Very High Very High Very High
Inflammation 577 98.32 Very High Very High Very High
Chronic pancreatitis 415 97.88 Very High Very High Very High
Multiple sclerosis 39 96.64 Very High Very High Very High
rheumatoid arthritis 106 96.04 Very High Very High Very High
Inflammatory mediators 15 93.44 High High
Central nervous system 16 91.60 High High
cytokine 121 89.04 High High
chemokine 63 89.00 High High
headache 2 80.28 Quite High
Disease Link Frequency Relevance Heat
Adenocarcinoma 1800 99.88 Very High Very High Very High
Hepatocellular Cancer 19 99.66 Very High Very High Very High
Pain 24 99.60 Very High Very High Very High
Communicable Diseases 4 99.58 Very High Very High Very High
Hookworm Infection 35 99.48 Very High Very High Very High
Cold Sores 203 99.42 Very High Very High Very High
Cancer 1378 99.38 Very High Very High Very High
Breast Cancer 136 99.36 Very High Very High Very High
Multiple Sclerosis 10 99.26 Very High Very High Very High
Apoptosis 406 99.20 Very High Very High Very High

[edit] Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results showed that ratings of unpleasantness and discomfort/pain were significantly decreased during DLPFC tDCS only, as compared to baseline and sham tDCS.
Negative_regulation (decreased) of tDCS associated with pain
1) Confidence 0.36 Published 2009 Journal Neuropsychologia Section Abstract Doc Link 18725237 Disease Relevance 0.83 Pain Relevance 0.89
The failure of DCs and other providers for that matter, to address the removable causes of disease in patients and communities is no longer professionally acceptable.
Negative_regulation (failure) of DCs associated with disease
2) Confidence 0.33 Published 2006 Journal Chiropr Osteopat Section Body Doc Link PMC1626475 Disease Relevance 0.41 Pain Relevance 0.09
This failure to normalize MDC in subjects with PDAC was also seen in a recent study 2.5 to 13 weeks post surgery [26] and Pinzon-Charry et al even found a further decrease in blood DCs six weeks post breast cancer surgery [31].
Negative_regulation (decrease) of DCs in blood associated with adenocarcinoma and breast cancer
3) Confidence 0.10 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2847547 Disease Relevance 1.75 Pain Relevance 0.19
Of note, a significant decrease in blood DCs was seen initially six weeks post the breast cancer surgery [31].
Negative_regulation (decrease) of DCs in blood associated with breast cancer
4) Confidence 0.10 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2847547 Disease Relevance 2.28 Pain Relevance 0.04
Several types of solid and blood cancers, such as pancreatic, breast, prostate, hepatocellular, lung, leukemia and squamous cell head and neck carcinomas, are accompanied by impaired function and reduced numbers of DCs [15-20].
Negative_regulation (numbers) of DCs in head associated with leukemia, cancer and carcinoma
5) Confidence 0.08 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2847547 Disease Relevance 1.27 Pain Relevance 0.15
Moreover, our findings indicate that patients with un-affected blood DC subsets pre and post, or with normalized DC numbers post surgery seems to have a survival benefit compared to individuals with impaired numbers of DCs.
Negative_regulation (impaired) of DCs in blood
6) Confidence 0.08 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2847547 Disease Relevance 1.05 Pain Relevance 0.09
Resection of the tumor should principally rescue the body from this chronic wound, but it seems likely that the healing process after surgery by itself contributes to the impairment of the circulating DCs as we found increased apoptosis in all pancreatic cancer groups and CP and even a further decrease in the frequency of DCs in many of subjects.
Negative_regulation (impairment) of DCs in body associated with cancer, pancreatic cancer, injury, apoptosis and chronic pancreatitis
7) Confidence 0.08 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2847547 Disease Relevance 1.88 Pain Relevance 0.24
This may not give the exact same levels as if analyzed as total numbers of PBMCs per ml blood but gives accurate values of the decrease in DCs occurring in individuals with pancreatic cancer compared to age matched healthy controls.
Negative_regulation (decrease) of DCs in blood associated with pancreatic cancer
8) Confidence 0.08 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2847547 Disease Relevance 1.10 Pain Relevance 0.15
Several solid cancers display impaired function and numbers of blood DCs [15-20,26,27].
Negative_regulation (numbers) of DCs in blood associated with cancer
9) Confidence 0.08 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2847547 Disease Relevance 1.97 Pain Relevance 0.32
Of note, both groups had decreased amount of total blood DCs compared to healthy controls (1.08%) (Figure 6A).
Negative_regulation (decreased) of DCs in blood
10) Confidence 0.08 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2847547 Disease Relevance 0.92 Pain Relevance 0.14
Conversely, the diminished levels of DCs could be due to the enhanced apoptosis seen in both DC subsets in individuals with PDAC and other types of cancers in the pancreas.
Negative_regulation (diminished) of DCs in pancreas associated with adenocarcinoma, cancer and apoptosis
11) Confidence 0.08 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2847547 Disease Relevance 1.46 Pain Relevance 0.09
IL-10 in serum from patients with hepatocellular carcinoma correlates with decreased number of DCs and immature DCs subsets [16].
Negative_regulation (decreased) of DCs associated with hepatocellular cancer
12) Confidence 0.08 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2847547 Disease Relevance 1.81 Pain Relevance 0.30
All groups examined, including PDAC, had decreased levels of myeloid DCs (MDC) and plasmacytoid DCs (PDC) and enhanced apoptosis in these cells as compared to controls.
Negative_regulation (decreased) of DCs in DCs associated with adenocarcinoma and apoptosis
13) Confidence 0.08 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2847547 Disease Relevance 2.25 Pain Relevance 0.33
Levels of these inflammatory factors were in part restored in PDAC after tumor resection, whereas the levels of DCs were impaired in the majority of these patients ~12 weeks after tumor removal.
Negative_regulation (impaired) of DCs in DCs associated with adenocarcinoma, inflammation and cancer
14) Confidence 0.08 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2847547 Disease Relevance 2.32 Pain Relevance 0.38
The number of peripheral blood DCs appears to be decreased in several types of cancer, including pancreatic cancer [15-20,31,32].
Negative_regulation (decreased) of DCs in blood associated with cancer and pancreatic cancer
15) Confidence 0.08 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2847547 Disease Relevance 1.15 Pain Relevance 0.04
Moreover, our findings indicate that patients with un-affected blood DC subsets pre and post, or with normalized DC numbers post surgery seems to have a survival benefit compared to individuals with impaired numbers of DCs.
Negative_regulation (numbers) of DCs in blood
16) Confidence 0.08 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2847547 Disease Relevance 0.99 Pain Relevance 0.04
This observation contrasts with the reduction in pDCs observed in blood from patients with systemic lupus erythematosus [41].
Negative_regulation (reduction) of pDCs in blood associated with systemic lupus erythematosus
17) Confidence 0.07 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 1.16 Pain Relevance 0.51
The present study demonstrates that Necator-infection impairs phenotypic differentiation and maturation of monocyte-derived DCs, mediated by hookworm ES products, and further inhibits DCs stimulatory function to allogeneic T cell proliferation in vitro.
Negative_regulation (inhibits) of DCs in DCs associated with hookworm infection and infection
18) Confidence 0.06 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.35 Pain Relevance 0.04
Functional impairment of DCs in patients with pancreatic ductal adenocarcinoma (PDAC), may contribute to the poor clinical outcome.
Negative_regulation (impairment) of DCs associated with adenocarcinoma
19) Confidence 0.05 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2955544 Disease Relevance 0.81 Pain Relevance 0.07
Although this comprehensive study expands and confirms recent reports suggesting a lack of interference of tDCS with an extracephalic reference electrode with vital functions [20-23,34,35], it has several limitations.
Negative_regulation (interference) of tDCS
20) Confidence 0.05 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844382 Disease Relevance 0.20 Pain Relevance 0.03

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