INT154375

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 1.28
Pain Relevance 2.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gars) ligase activity (Gars) cytoplasm (Gars)
Anatomy Link Frequency
neurons 2
plasma 1
Internal 1
Gars (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 113 99.60 Very High Very High Very High
spinal dorsal horn 170 99.42 Very High Very High Very High
agonist 2 99.16 Very High Very High Very High
Cannabinoid 10 98.98 Very High Very High Very High
Hippocampus 110 98.64 Very High Very High Very High
Pain 64 96.00 Very High Very High Very High
antagonist 30 95.36 Very High Very High Very High
IPN 20 94.36 High High
Endocannabinoid 1 94.36 High High
Analgesic 2 92.76 High High
Disease Link Frequency Relevance Heat
Pain 54 96.00 Very High Very High Very High
Inflammatory Pain 20 94.36 High High
Nociception 40 88.88 High High
Decapitation 10 80.52 Quite High
Epilepsy 20 71.84 Quite High
Premenstrual Syndrome 60 68.24 Quite High
Disease 21 67.44 Quite High
Affective Disorder 10 60.72 Quite High
Anxiety Disorder 20 40.20 Quite Low
Convulsion 10 39.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In HEK293 cells expressing recombinant GlyRs, we found that E2 significantly inhibited ?
Gene_expression (expressing) of GlyRs
1) Confidence 0.37 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0 Pain Relevance 0.11
In addition, E2 inhibited the recombinant GlyRs expressed in HEK293 cells which are devoid of classical ERs [45].
Gene_expression (expressed) of GlyRs
2) Confidence 0.37 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0.12 Pain Relevance 0.11
Expression of recombinant GlyRs
Gene_expression (Expression) of GlyRs
3) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0.08 Pain Relevance 0.04
The membrane capacitance was not changed by E2, indicating that the alteration of plasma membrane capacitance was not involved in E2 inhibition of GlyRs.


Neg (inhibition) Gene_expression (inhibition) of GlyRs in plasma
4) Confidence 0.32 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0 Pain Relevance 0.04
GlyRs are pentamers and composed of ?
Gene_expression (pentamers) of GlyRs
5) Confidence 0.32 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0.13 Pain Relevance 0.41
Regulatory sites for E2 and pregnanolone on GlyRs are separate
Gene_expression (pregnanolone) of GlyRs
6) Confidence 0.32 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0 Pain Relevance 0.07
To determine which GlyR subunits are responsible for the E2-induced inhibition, we investigated the E2 effects on IGly in HEK293 cells expressing various recombinant GlyRs (Figure 4A).
Gene_expression (expressing) of GlyRs
7) Confidence 0.32 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0 Pain Relevance 0
-GlyRs expressed in HEK293 cells, providing important insights into the mechanisms underlying gender differences in pain sensation at the CNS level.
Gene_expression (expressed) of GlyRs associated with pain
8) Confidence 0.28 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0.67 Pain Relevance 0.63
2-GlyRs [51-53], were reduced to a level compatible with that measured in cultured neurons or HEK 293 cells expressing recombinant GlyRs.
Gene_expression (expressing) of GlyRs in neurons
9) Confidence 0.28 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0 Pain Relevance 0.22
-estradiol (E2), the most prevalent and potent form of endogenous estrogen, on native GlyRs in HIP and SDH neurons, and on recombinant GlyRs expressed in HEK293 cells.
Gene_expression (expressed) of GlyRs in neurons associated with spinal dorsal horn
10) Confidence 0.28 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0.12 Pain Relevance 0.35
Internal consistency was investigated for all subscales of the SIP-136, SF-36 and GARS by calculating Cronbach's alpha (?).
Spec (investigated) Gene_expression (subscales) of GARS in Internal
11) Confidence 0.12 Published 2010 Journal J Trauma Manag Outcomes Section Body Doc Link PMC2909985 Disease Relevance 0.07 Pain Relevance 0.07
The present study characterised the effects of cannabinoid agonists on alpha1, alpha1beta, alpha2 and alpha3 GlyRs recombinantly expressed in HEK293 cells with the aims of reconciling effects of cannabinoids on these receptor subtypes and to establish the potential of different GlyR isoforms as novel physiological or analgesic targets for cannabinoids.
Gene_expression (expressed) of GlyRs associated with analgesic, cannabinoid and agonist
12) Confidence 0.07 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18755158 Disease Relevance 0.09 Pain Relevance 0.64

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