INT154388

Context Info Confidence 0.67 First Reported 2006 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 9 Total Number 9 Disease Relevance 7.75 Pain Relevance 1.72

extracellular region (DEFB4A)

Anatomy Link Frequency epithelial cells 2 keratinocytes 2 DEFB4A (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 126 99.84 psoriasis 250 97.64 rheumatoid arthritis 50 86.52 Inflammation 78 85.76 Arthritis 5 62.32 spastic colon 4 50.00 chemokine 7 27.44 Inflammatory response 2 17.00 cINOD 5 5.00 Crohn's disease 5 5.00

Disease Link Frequency Relevance Heat Eczema 95 100.00 Hemophilus Infection 80 98.44 Disease 191 97.84 Psoriasis 345 97.64 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 2 88.92 Functional Bowel Disorder 4 88.72 Diarrhoea 4 87.24 Infection 17 86.80 Rheumatoid Arthritis 50 86.52 INFLAMMATION 81 85.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

CONCLUSION: The expressions of HBD-2 and TNF-at are significantly increased in UC, but are not correlated with IBS-D and the severity of clinical symptoms of UC patients.

Positive_regulation (increased) of Gene_expression (expressions) of HBD-2

1) Confidence 0.67 Published 2008 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 18756966 Disease Relevance 0.12 Pain Relevance 0

We could indeed show that Th2 cytokines do not induce hBD-2 expression in cultured keratinocytes [18] and that Th2 cytokines repress the Th1 induced expression (not shown here), as was previously shown for hBD-3 [43].

Neg (not) Positive_regulation (induce) of Gene_expression (expression) of hBD-2 in keratinocytes associated with cytokine

2) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 1.12 Pain Relevance 0.48

-defensin 2 (DEFB4) promoter construct was transfected into HMEEC followed by treatment with NTHi lysate and IL-1?

Positive_regulation (transfected) of Gene_expression (transfected) of DEFB4 associated with hemophilus infection

3) Confidence 0.49 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1368979 Disease Relevance 0.97 Pain Relevance 0

METHODS: Immunohistochemistry was conducted on the biopsy samples of colonic mucosa from 30 UC patients, 20 IBS-D patients, and 10 normal persons to measure the expression of HBD-2 and TNF-alpha.

Positive_regulation (measure) of Gene_expression (expression) of HBD-2

4) Confidence 0.48 Published 2008 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 18756966 Disease Relevance 0.18 Pain Relevance 0

As previously reported [10], hBD-2 protein is expressed at low to undetectable levels (immunohistochemistry) in lesional atopic dermatitis, despite strong induction at the mRNA level.

Positive_regulation (induction) of Gene_expression (expressed) of hBD-2 protein associated with eczema

5) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 1.72 Pain Relevance 0.39

Although our findings indicate that uninduced hBD-2 production is subject to gene dosage effects, the high systemic serum levels in psoriasis patients are caused by disease activity itself.

Positive_regulation (uninduced) of Gene_expression (production) of hBD-2 associated with psoriasis and disease

6) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.77 Pain Relevance 0.20

Although our findings indicate that uninduced hBD-2 production is subject to gene dosage effects, the high systemic serum levels in psoriasis patients are caused by disease activity itself.

Positive_regulation (subject) of Gene_expression (production) of hBD-2 associated with psoriasis and disease

7) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.83 Pain Relevance 0.20

In sera from 8 patients with moderate to severe atopic dermatitis we found that, although serum hBD-2 levels were significantly higher than in control sera (t-test, p<10?

Positive_regulation (serum) of Gene_expression (levels) of hBD-2 associated with eczema

8) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 1.72 Pain Relevance 0.36

-defensin family appear to be expressed by most epithelial cells of the small and large intestine, HBD-1 being expressed constitutively, while HBD-2 synthesis is induced by activation of the transcriptional factor NF?

Positive_regulation (induced) of Gene_expression (synthesis) of HBD-2 in epithelial cells

9) Confidence 0.16 Published 2010 Journal Eplasty Section Body Doc Link PMC2803769 Disease Relevance 0.17 Pain Relevance 0.08

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