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Context Info
Confidence 0.69
First Reported 1989
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 32
Total Number 33
Disease Relevance 12.76
Pain Relevance 9.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plat) extracellular space (Plat) extracellular region (Plat)
molecular_function (Plat) cytoplasm (Plat)
Anatomy Link Frequency
blood 3
dorsal horn 2
sciatic nerve 2
plasma 1
platelet 1
Plat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 12 100.00 Very High Very High Very High
Sciatica 8 100.00 Very High Very High Very High
Glutamate 1 100.00 Very High Very High Very High
dexamethasone 2 99.96 Very High Very High Very High
Dorsal horn 33 99.68 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 15 99.68 Very High Very High Very High
Morphine 9 99.66 Very High Very High Very High
Angina 27 99.60 Very High Very High Very High
Peripheral nerve injury 13 99.40 Very High Very High Very High
IPN 5 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cardiovascular Disease 62 100.00 Very High Very High Very High
Cv General 3 Under Development 25 99.60 Very High Very High Very High
Myocardial Infarction 38 99.48 Very High Very High Very High
Nervous System Injury 16 99.40 Very High Very High Very High
Pulmonary Embolism 28 99.36 Very High Very High Very High
Thrombosis 42 99.28 Very High Very High Very High
Hypertension 9 98.92 Very High Very High Very High
Peripheral Arterial Disease 1 98.60 Very High Very High Very High
Coronary Artery Disease 17 98.32 Very High Very High Very High
Obesity 6 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tissue type plasminogen activator induced in rat dorsal horn astrocytes contributes to mechanical hypersensitivity following dorsal root injury.
Positive_regulation (induced) of Tissue type plasminogen activator in dorsal horn associated with injury, hypersensitivity, sciatica and dorsal horn
1) Confidence 0.69 Published 2007 Journal Glia Section Title Doc Link 17299772 Disease Relevance 0.68 Pain Relevance 0.70
In the present study, we found a marked induction of tPA in activated astrocytes following L4/5 root injury and a resultant increase of proteolytic enzymatic activity in the dorsal horn.
Positive_regulation (induction) of tPA in astrocytes associated with injury and dorsal horn
2) Confidence 0.69 Published 2007 Journal Glia Section Abstract Doc Link 17299772 Disease Relevance 0.96 Pain Relevance 0.70
We found the induction of mRNAs for tissue type plasminogen activator (tPA) and urokinase plasminogen activator (uPA) in the rat dorsal root ganglia following sciatic nerve transection.
Positive_regulation (induction) of tissue type plasminogen activator in sciatic nerve associated with sciatic nerve
3) Confidence 0.67 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 14750967 Disease Relevance 0.41 Pain Relevance 0.49
Immunoreactivity for tPA was increased in laminae I and II of the dorsal horn and, importantly, the increase in proteolytic activity mediated by tPA was observed in the same area.
Positive_regulation (increased) of tPA in dorsal horn associated with dorsal horn
4) Confidence 0.67 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 14750967 Disease Relevance 0.47 Pain Relevance 0.61
We found the induction of mRNAs for tissue type plasminogen activator (tPA) and urokinase plasminogen activator (uPA) in the rat dorsal root ganglia following sciatic nerve transection.
Positive_regulation (induction) of tPA in sciatic nerve associated with sciatic nerve
5) Confidence 0.67 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 14750967 Disease Relevance 0.41 Pain Relevance 0.49
These findings suggest that the increased tPA in the dorsal horn due to mRNA expression in the dorsal root ganglia increases the dorsal horn excitability and has an important role in pain behaviour after peripheral nerve injury.
Positive_regulation (increased) of tPA in peripheral nerve associated with pain, nervous system injury, dorsal horn and peripheral nerve injury
6) Confidence 0.67 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 14750967 Disease Relevance 0.65 Pain Relevance 1.02
Psychostimulants strongly induce their expression in the mesolimbic dopaminergic pathway, but cocaine preferentially induces uPA, whereas morphine and amphetamine preferentially induce tPA. tPA-expressing animals displayed enhanced conditional place preference (CPP) for amphetamine compared with uPA-overexpressing animals.
Positive_regulation (induce) of tPA associated with morphine and cocaine
7) Confidence 0.48 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 18256596 Disease Relevance 0.09 Pain Relevance 0.15
HPLC analysis of the perfusate obtained by microdialysis in vivo showed a significant increase in the extracellular levels of aspartate, glutamate, glycine and taurine, and a decrease of the glutamine level during TPA infusion.
Positive_regulation (increase) of TPA associated with glutamate
8) Confidence 0.38 Published 1999 Journal Pain Section Abstract Doc Link 10342421 Disease Relevance 0.15 Pain Relevance 0.66
[A case of successful tissue plasminogen activator in young-onset pulmonary embolism].
Positive_regulation (successful) of tissue plasminogen activator associated with pulmonary embolism and cva
9) Confidence 0.31 Published 1993 Journal Kokyu To Junkan Section Title Doc Link 8484062 Disease Relevance 0.79 Pain Relevance 0.23
We investigated whether the clinical evolution of symptoms in patients admitted with unstable angina is associated with changes in t-plasminogen activator antigen (t-PA) and von Willebrand (vW) factor levels.
Spec (whether) Positive_regulation (changes) of t-PA associated with angina
10) Confidence 0.29 Published 1996 Journal Int. J. Cardiol. Section Abstract Doc Link 8792192 Disease Relevance 0.17 Pain Relevance 0.23
Fluctuations in tissue plasminogen activator (t-PA) activity, t-PA antigen, and plasminogen activator inhibitor-I (PAI-1) antigen levels were evaluated in blood samples obtained from 84 patients with initial uneventful acute myocardial infarction (AMI) and 35 patients with reinfarction and fatal infarction (patients with bad prognoses).
Positive_regulation (Fluctuations) of tissue plasminogen in blood associated with infarction and myocardial infarction
11) Confidence 0.28 Published 1996 Journal J Cardiol Section Abstract Doc Link 8642503 Disease Relevance 0.55 Pain Relevance 0.07
Fluctuations in tissue plasminogen activator (t-PA) activity, t-PA antigen, and plasminogen activator inhibitor-I (PAI-1) antigen levels were evaluated in blood samples obtained from 84 patients with initial uneventful acute myocardial infarction (AMI) and 35 patients with reinfarction and fatal infarction (patients with bad prognoses).
Positive_regulation (Fluctuations) of t-PA in blood associated with infarction and myocardial infarction
12) Confidence 0.28 Published 1996 Journal J Cardiol Section Abstract Doc Link 8642503 Disease Relevance 0.56 Pain Relevance 0.07
Fluctuations in tissue plasminogen activator (t-PA) activity, t-PA antigen, and plasminogen activator inhibitor-I (PAI-1) antigen levels were evaluated in blood samples obtained from 84 patients with initial uneventful acute myocardial infarction (AMI) and 35 patients with reinfarction and fatal infarction (patients with bad prognoses).
Positive_regulation (Fluctuations) of t-PA in blood associated with infarction and myocardial infarction
13) Confidence 0.28 Published 1996 Journal J Cardiol Section Abstract Doc Link 8642503 Disease Relevance 0.55 Pain Relevance 0.07
Known activators of PKC, 12-O-tetradecanoylphorbol 13-acetate (TPA) and 1,2-dioctanoyl-sn-glycerol, abolished gap junctional communication at nanomolar concentrations.
Positive_regulation (activators) of TPA associated with kinase c
14) Confidence 0.28 Published 1995 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 7532876 Disease Relevance 0 Pain Relevance 0.32
Although the numbers of patients with ST shift were similar, the duration of ST shift was significantly longer in the patients receiving t-PA than with placebo (20 +/- 46 versus 3 +/- 10 minutes, p less than 0.045).
Positive_regulation (receiving) of t-PA
15) Confidence 0.27 Published 1992 Journal Circulation Section Body Doc Link 1728444 Disease Relevance 0 Pain Relevance 0
Patients with initial AMI had significantly higher levels of t-PA activity than those of 14 patients with angina pectoris.
Positive_regulation (levels) of t-PA associated with angina and myocardial infarction
16) Confidence 0.26 Published 1996 Journal J Cardiol Section Abstract Doc Link 8642503 Disease Relevance 0.78 Pain Relevance 0.17
Paradoxically, there appears to be an increase in ST shift and worsening of myocardial perfusion with t-PA compared with therapy with heparin alone.


Positive_regulation (increase) of t-PA
17) Confidence 0.25 Published 1992 Journal Circulation Section Body Doc Link 1728444 Disease Relevance 0 Pain Relevance 0
An upregulation of tissue plasminogen activator (plat) by 3.74 ± 0.83 and plasminogen activator inhibitor-2 (Serpinb2) by 2.68 ± 0.83 foldwith MCT treatment was also observed.
Positive_regulation (upregulation) of tissue plasminogen activator
18) Confidence 0.24 Published 2005 Journal Respir Res Section Body Doc Link PMC1291406 Disease Relevance 0.35 Pain Relevance 0.03
Porous structure of hydrogel was essential in this system to yield a large surface area so that t-PA release could be facilitated.
Positive_regulation (facilitated) of t-PA
19) Confidence 0.21 Published 2001 Journal J Control Release Section Abstract Doc Link 11451495 Disease Relevance 0.09 Pain Relevance 0.27
Diurnal variation of tissue-type plasminogen activator and its rapid inhibitor (PAI-1).
Positive_regulation (variation) of tissue-type plasminogen activator
20) Confidence 0.19 Published 1989 Journal Circulation Section Title Doc Link 2491971 Disease Relevance 0.15 Pain Relevance 0.07

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